以G蛋白偶联受体为靶标的自身免疫性疾病的治疗（英文）

发布时间：2018-05-04 11:31

本文选题：G + protein-coupled　；参考：《中国药理学与毒理学杂志》2017年10期

【摘要】：Our group is interested in the biological functions of G protein-coupled receptor(GPCR)and their roles in major diseases including autoimmune disease,neurodegenerative diseases,metabolic diseases,etc.In addition to the mechanism study,we also screen and develop drugs targeting GPCRs.In recent years,we also seek to study the mechanism of fate determination of stem cells with small molecule compounds.One of the autoimmune diseases we′re particularly interested is Multiple Sclerosis(MS).MS is an inflammatory disease that is characterized by immune-mediated demyelination and degeneration of the central nervous system.In the past few years,we′ve discovered that two GPCRs(CysLT1 and A2B)are critically involved in the development of MS by regulating the differentiation or function of immune cells.Blocking these receptors alleviates clinical symptoms of EAE,a mouse model of MS,indicating these receptors are potential drug targets for MS.Current drugs for MS all targets immune system.Although effective in reducing the relapse rate and the formation of new lesions,these drugs have very limited effects in preventing the progression of disability.Promoting oligodendrocyte progenitor cell differentiation,remyelination and subsequent functional recovery of the neurons have been proposed to be the new direction of MS therapy.Our recent study demonstrated that KOR,an opioid receptor,is important for oligodendrocyte-mediated remyelination in EAE,suggesting KOR might be a target to develop new MS therapies from a regenerative point of view.
[Abstract]:Our group is interested in the biological functions of G protein-coupled receptor(GPCR)and their roles in major diseases including autoimmune disease,neurodegenerative diseases,metabolic diseases,etc.In addition to the mechanism study,we also screen and develop drugs targeting GPCRs.In recent years,we also seek to study the mechanism of fate determination of stem cells with small molecule compounds.One of the autoimmune diseases we're particularly interested is Multiple Sclerosis(MS).MS is an inflammatory disease that is Characterized by immune-mediated demyelination and degeneration of the central nervous system.In the past few yearsweve discovered that two GPCRs(CysLT1 and A2B)are critically involved in the development of MS by regulating the differentiation or function of immune cells.Blocking these receptors alleviates clinical symptoms of EAE a mouse model of MSindicating these receptors are potential drug targets for MS.Current drugs for MS all targets immune system.Although effective in reducing the relapse Rate and the formation of new lesions,these drugs have very limited effects in preventing the progression of disability.Promoting oligodendrocyte progenitor cell differentiation,remyelination and subsequent functional recovery of the neurons have been proposed to be the new direction of MS therapy.Our recent study demonstrated that KOR,an opioid receptor,is important for oligodendrocyte-mediated remyelination in EAE,suggesting KOR might be a target to develop new MS therapies from a regenerative point of view.
【作者单位】： The
【分类号】：R593.2

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