DPP-4抑制剂西格列汀治疗新诊断老年2型糖尿病的疗效及其对血压、体质量的影响研究

发布时间：2018-05-04 11:03

本文选题：DPP-抑制剂 + 西格列汀　；参考：《重庆医学》2017年11期

【摘要】：目的探讨DPP-4抑制剂西格列汀治疗新诊断老年2型糖尿病的临床疗效及其对血压、体质量的影响。方法选取该院2013年7月至2015年6月收治的100例新诊断老年2型糖尿病患者作为研究对象,将其分为观察组和对照组,每组50例。对照组在饮食控制及锻炼的基础上使用安慰剂进行治疗,观察组在饮食控制及锻炼基础上使用西格列汀进行治疗。对比患者治疗前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化清蛋白(GA)的变化情况,监测低血糖发生率、血压、体质量等变化及不良反应。结果治疗后,两组患者的病情均明显好转,且观察组FPG、2hPG、GA的变化情况均显著优于对照组,差异有统计学意义(P0.05)。治疗后,两组患者血压、体质量和BMI与治疗前比较差异均无统计学意义(P0.05)。治疗后,观察组与对照组不良反应发生率分别为10.0%和8.0%,差异无统计学意义(P0.05)。结论应用DPP-4抑制剂西格列汀治疗新诊断老年2型糖尿病患者临床疗效好。
[Abstract]:Objective to investigate the clinical efficacy of DPP-4 inhibitor siglitatin in the treatment of newly diagnosed type 2 diabetes mellitus and its effect on blood pressure and body mass. Methods from July 2013 to June 2015, 100 newly diagnosed elderly patients with type 2 diabetes mellitus were selected and divided into observation group and control group with 50 cases in each group. The control group was treated with placebo on the basis of diet control and exercise, while the observation group was treated with siglitatin on the basis of diet control and exercise. The changes of fasting blood glucose (FPG), 2 h postprandial blood glucose (2 h) and glycosylated albumin (GAA) were compared before and after treatment. The incidence of hypoglycemia, blood pressure, body mass and adverse reactions were monitored. Results after treatment, the condition of patients in both groups was obviously improved, and the changes of PGGA in the observation group were significantly better than those in the control group, and the difference was statistically significant (P 0.05). After treatment, there was no significant difference in blood pressure, body mass and BMI between the two groups. After treatment, the incidence of adverse reactions in the observation group and the control group was 10.0% and 8.0%, respectively, with no significant difference (P 0.05). Conclusion DPP-4 inhibitor siglitatin is effective in the treatment of newly diagnosed elderly type 2 diabetes.
【作者单位】：福建医科大学附属闽东医院内分泌科;福建医科大学附属闽东医院眼科;
【基金】：宁德市科学技术计划项目(20130144)
【分类号】：R587.1

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