促甲状腺激素水平与老年2型糖尿病患者骨密度的相关性研究

发布时间：2018-05-04 19:49

本文选题：型糖尿病 + 促甲状腺激素　；参考：《中国骨质疏松杂志》2017年02期

【摘要】：目的探讨老年2型糖尿病患者血清促甲状腺激素水平对骨代谢的影响及临床意义。方法选取172例甲状腺激素水平正常的老年2型糖尿病(2DM)患者,采用双能X线骨密度仪进行腰椎L1-4骨密度测量,按T值分为骨量正常组(NC)和骨量减少/骨质疏松组(OP)。记录各组患者年龄、性别、身高、体重,计算体重指数(BMI),检测空腹血糖(FPG)、糖化血红蛋白(Hb A1c)、25羟维生素D3(25-OH-D3),N端骨钙素(NMID)、I型胶原羧基末端肽β特殊序列(βCTX)、I型前胶原羧基末端肽(PICP)、促甲状腺激素(TSH)水平。结果与NC组相比,OP组TSH、BMI偏低,差异有统计学意义(P0.05)。骨代谢指标中,OP组I型胶原羧基末端肽β特殊序列(βCTX)明显高于NC组(P0.01),而I型前胶原羧基末端肽(PICP)明显低于NC组(P0.01)。BMD与TSH、BMI呈正相关。多元逐步回归结果提示,TSH和BMI是腰椎骨密度的主要影响因素。结论老年2型糖尿病患者骨密度与TSH水平密切相关,TSH水平偏低的老年2型糖尿病患者更容易发生骨密度的降低。
[Abstract]:Objective to investigate the effect of serum thyroid stimulating hormone (TSH) on bone metabolism in elderly patients with type 2 diabetes mellitus and its clinical significance. Methods L1-4 bone mineral density of lumbar vertebrae was measured by dual energy X-ray absorptiometry in 172 elderly patients with type 2 diabetes mellitus with normal thyroid hormone level. According to T value, bone mass was divided into two groups: normal bone mass group (NC3) and osteopenia group (osteopenia / osteoporosis group). Age, sex, height, weight of patients in each group were recorded. Body mass index (BMI), fasting blood glucose (FBG), HbA1cU 25 hydroxyvitamin D ~ (3 +) 25-OH-D _ (3) and N-terminal osteocalcin I type I collagen carboxyl terminal peptide 尾 (尾 CTX) I procollagen carboxyl terminal peptide (PICPN) were measured. Results compared with NC group, the BMI of TSHN in op group was lower than that in NC group, and the difference was statistically significant (P 0.05). In bone metabolism, the 尾 CTXs of type I collagen carboxyl terminal peptide 尾 (尾 CTX) in op group were significantly higher than those in NC group (P 0.01), while PICP of type I procollagen carboxyl terminal peptide (PICP) was significantly lower than that of NC group (P 0.01). BMD was positively correlated with TSHN BMI. Multiple stepwise regression analysis showed that TSH and BMI were the main influencing factors of lumbar bone mineral density. Conclusion the bone mineral density (BMD) is closely related to the TSH level in the elderly type 2 diabetes mellitus patients with low TSH level are more likely to develop BMD reduction in the elderly patients with type 2 diabetes mellitus.
【作者单位】：上海市杨浦区市东医院内分泌科;上海市同济大学附属同济医院内分泌科;
【分类号】：R587.1

【相似文献】