脂肪干细胞治疗支气管哮喘的机制与潜力

发布时间：2018-05-06 22:43

  本文选题：干细胞 + 哮喘　； 参考：《中国组织工程研究》2017年13期

【摘要】：背景:目前临床上治疗哮喘仍然是以吸入性糖皮质激素为主的经典治疗方法。成体干细胞治疗在多种疾病中取得了一定的发展,为治疗哮喘提供了新思路。目的:从脂肪干细胞及相关成体干细胞在治疗哮喘中的治疗机制进行综述,了解目前脂肪干细胞治疗哮喘的最新进展及其治疗安全性以及在未来哮喘治疗中可能的研究方向。方法:在Pub Med中以(adipose-derived stem cells[All Fields])OR(adipose stem cells[All Fields])OR(adipose-derived mesenchymal stem cells[All Fields])AND(asthma[All Fields])为检索式来检索,在CBM、CNKI及万方医学分别以("脂肪干细胞"[常用字段:智能])OR("脂肪间充质干细胞"[常用字段:智能])OR("脂肪来源的干细胞"[常用字段:智能])AND("哮喘"[常用字段:智能])为检索式来检索2001至2016年的相关文献。结果与结论:通过浏览文章标题、摘要和全文来筛选目标文献,共检索到125篇文献,最终筛选出54篇代表文献。脂肪干细胞干预哮喘小鼠可能通过免疫调节降低气道炎症、气道高反应并减少上皮下胶原沉积及瘢痕组织形成,促进新生血管生长,重建损伤的气道。但将脂肪干细胞引入常规临床治疗之前还需深入研究其治疗的作用机制及进行必要的基因组分析。脂肪干细胞在治疗哮喘等气道过敏性炎症疾病中可能具有较大潜力。
[Abstract]:Background: currently, asthma treatment is still a classical treatment based on inhaled glucocorticoid. Adult stem cell therapy has made some progress in many diseases, which provides a new idea for the treatment of asthma. Aim: to review the therapeutic mechanism of adipose stem cells and related adult stem cells in the treatment of asthma, and to understand the latest progress and safety of adipose stem cells in the treatment of asthma, as well as the possible research directions in the treatment of asthma in the future. Methods: Pub Med was used to retrieve adipose-derived stem cells [All Fields] oradipose-derived mesenchymal stem cells [All Fields] ANDasthma [All Fields]. In CBMU CNKI and Wanfang Medicine ("Adipose Stem Cell" [often used word: intelligence] Orr ("adipose Mesenchymal Stem Cell" [often used word: intelligence] Orr ("Fat derived Stem Cell" [often used word: intelligence] AND ("Asthma" [often used: intelligence]) Search for relevant literature from 2001 to 2016. Results & conclusion: a total of 125 articles were retrieved and 54 representative articles were screened by browsing the title, abstracts and full text of the articles. The intervention of adipose stem cells in asthma mice may reduce airway inflammation, airway hyperresponsiveness, decrease collagen deposition and scar formation, promote neovascularization and reconstruct damaged airway through immunomodulation. However, the mechanism of adipose stem cells and the necessary genome analysis should be further studied before introducing them into routine clinical therapy. Adipose stem cells may have great potential in the treatment of allergic airway diseases such as asthma.
【作者单位】： 遵义医学院附属医院呼吸二科;
【基金】：贵州省科学技术基金项目(黔科合J字[2013]2329号)~~
【分类号】：R562.25
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本文编号：1854260