RANTES、MCP-1和SDF-1β在正常人体和AIDS患者体内含量的对比研究
发布时间：2018-05-06 23:28
本文选题：获得性免疫缺陷综合征 + 人类免疫缺陷病毒 ； 参考：《中国感染控制杂志》2017年09期
【摘要】：目的探讨血清趋化因子(RANTES)、单核细胞趋化蛋白1(MCP-1)、基质细胞衍生因子-1β(SDF-1β)在获得性免疫缺陷综合征(AIDS)和正常人体内的差异。方法选择2010年1月—2015年1月某院收集的38例AIDS患者作为AIDS组,38例健康者作为健康组,检测两组血清RANTES、MCP-1、SDF-1β水平,并根据病毒载量进行亚组分析。结果 AIDS组患者血清中RANTES、MCP-1、SDF-1β水平分别为(1 392.55±227.69)、(450.91±103.04)、(104.82±22.52)pg/mL,均高于健康组[分别为(120.58±55.87)、(74.25±33.62)、(39.04±11.43)pg/mL],差异均具有统计学意义(均P0.05)。HIV病毒载量4≤Log(VL)5、Log(VL)≥5的AIDS患者血清中RANTES水平分别为(1 470.34±155.01)、(1 408.29±181.54)pg/mL,均高于Log(VL)4组患者[(1 183.12±174.54)pg/mL];HIV病毒载量4≤Log(VL)5的AIDS患者血清中MCP-1、SDF-1β水分别为(537.93±89.32)、(149.31±18.05)pg/mL,高于Log(VL)≥5组[分别为(410.26±80.57)、(81.53±20.31)pg/mL]和Log(VL)4组患者[分别为(381.71±77.26)、(72.90±21.62)pg/mL],差异均有统计学意义(均P0.05)。结论 AIDS患者血清RANTES、MCP-1、SDF-1β水平显著升高,且与病毒载量水平有一定的关系。
[Abstract]:Objective to investigate the difference of serum chemokine RANTES1, monocyte chemoattractant protein 1 (MCP-1P) and stromal cell derived factor 1 尾 (SDF-1 尾) in acquired immunodeficiency syndrome (AIDS) and normal volunteers. Methods 38 patients with AIDS collected from January 2010 to January 2015 were selected as AIDS group and 38 healthy persons as healthy group. The serum levels of RANTES MCP-1and SDF-1 尾 were detected and subgroup analysis was performed according to the viral load. 缁撴灉 AIDS缁勬偅鑰呰娓呬腑RANTES,MCP-1,SDF-1尾姘村钩鍒嗗埆涓，
本文编号：1854388
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