白三烯B4与类风湿关节炎的治疗

发布时间：2018-05-07 01:41

本文选题：类风湿关节炎 + 白三烯B　；参考：《中国老年学杂志》2016年07期

【摘要】：正类风湿关节炎(RA)病理机制未明,目前对RA的治疗主要集中在控制疼痛和炎症、阻断骨质破坏的发展以及改善关节功能上~(〔1〕)。传统治疗药物由于其系统用药的特性,在治疗的同时也产生一定的不良反应。白三烯(LT)B4是白细胞产生的一种脂质介质,系膜磷脂在磷脂酶(PL)A2作用下的花生四烯酸(AA)下游产物。研究证明在RA患者的关节腔和滑液中存在高浓度的LTB4,且大量文献证明LTB4在RA的发病机制中发
[Abstract]:The pathological mechanism of rheumatoid arthritis (RA) is not clear. At present, the treatment of RA mainly focuses on controlling pain and inflammation, blocking the development of bone destruction and improving the function of the joint. Because of its systematic characteristics, traditional treatment drugs also produce some adverse reactions. Leukotriene LTT B4 is a kind of lipid medium produced by white blood cells. The downstream product of Mesangial phospholipids is arachidonic acid (AA) under the action of phospholipase (PLA 2). Studies have shown that there is a high concentration of LTB4 in articular cavity and synovial fluid of RA patients, and a large number of literatures have proved that LTB4 may play an important role in the pathogenesis of RA.
【作者单位】：南昌大学医学部生理教研室;南昌大学;南昌大学医学实验教学部;南昌大学基础医学院;
【基金】：国家自然科学基金项目(81260504) 南昌大学校级教学改革研究课题(NCUJGLX-14-1-111,NCUJGLX-14-1-72)
【分类号】：R593.22

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