亚临床甲状腺功能减退与糖尿病患者微血管并发症的相关性

发布时间：2018-05-07 15:24

本文选题：甲状腺功能 + 糖尿病微血管并发症　；参考：《中国老年学杂志》2017年11期

【摘要】：目的研究亚临床状态甲状腺功能减退(SCH)与糖尿病微血管并发症的关系。方法 80例2型糖尿病(T2DM)患者中SCH患者40例(SCH组)和甲状腺功能正常者40例(对照组)。比较两组性别、年龄,吸烟饮酒史,糖尿病病程,体质量指数,血压,促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、甲状腺过氧化物抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)、血糖、血脂、糖化血红蛋白(HbA1c)、糖尿病肾病(DN)、糖尿病视网膜病变(DR)、糖尿病周围神经病变(DP)情况。关联性分析采用Spearman相关分析,Logistic多因素分析。结果 SCH组TSH、TgAb、TPOAb明显高于对照组,FT4明显低于对照组(均P0.05);Logistic回归多因素分析显示,经校正后DN、低FT4、高TSH、高Tg Ab、高TPOAb均为糖尿病微血管并发症发生的危险因素(P0.05)。结论 SCH可促进糖尿病的进程,与糖尿病微血管并发症密切相关,提示有必要对T2DM患者定期进行甲状腺功能检查,以便及早诊断和干预,从而预防和延缓糖尿病并发症的发生和发展。
[Abstract]:Objective to study the relationship between subclinical hypothyroidism and diabetic microvascular complications. Methods 80 patients with type 2 diabetes mellitus (T2DM), 40 patients with SCH and 40 patients with normal thyroid function (control group) were included. Sex, age, history of smoking and drinking, course of diabetes, body mass index, blood pressure were compared between the two groups. Thyroid stimulating hormone TSHN, free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase (TPO) antibody, thyroglobulin antibody (TGP), blood glucose, blood lipid, Glycosylated hemoglobin (HbA1cN), diabetic nephropathy (DN), diabetic retinopathy (DRN), diabetic peripheral neuropathy (DPN). Spearman correlation analysis and Logistic multivariate analysis were used in the correlation analysis. Results compared with the control group, SCH group was significantly higher than the control group (P 0.05). Logistic regression analysis showed that DN, low FT _ 4, high TG Aband and high TPOAb were the risk factors of diabetic microvascular complications (P 0.05). Conclusion SCH can promote the progression of diabetes mellitus and is closely related to diabetic microvascular complications. It suggests that it is necessary to regularly examine thyroid function in patients with T2DM for early diagnosis and intervention. In order to prevent and delay the occurrence and development of diabetic complications.
【作者单位】：锦州医科大学附属第一医院内分泌科;锦州市中心医院神经内科;武警辽宁总队本溪支队卫生队;
【基金】：辽宁省教育厅课题(No.L2013325) 辽宁省大学生创新创业训练项目(No.201310160008)
【分类号】：R581.2;R587.2

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