苯溴马隆片与别嘌醇片治疗急性脑梗死伴高尿酸血症的临床研究

发布时间：2018-05-09 04:15

本文选题：苯溴马隆片 + 别嘌醇片　；参考：《中国临床药理学杂志》2017年19期

【摘要】：目的比较苯溴马隆与别嘌醇对急性脑梗死合并高尿酸血症患者的临床疗效和安全性。方法将180例急性脑梗死并且合并高尿酸血症患者随机分为对照组60例,试验A组60例,试验B组60例,3组患者均给予脑梗死常规治疗。对照组给予安慰剂(淀粉胶囊)25 mg,qd,口服。试验A组给予别嘌醇100mg,bid,口服。试验B组给予苯溴马隆50 mg,qd,口服。3组患者均治疗14 d。观察3组患者的临床疗效,血尿酸(UA)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、颈动脉内膜中膜厚度(IMT)的变化以及药物不良反应的发生情况。结果治疗后,试验A组、试验B组和对照组的总有效率分别为88.33%(53/60例),95.00%(57/60例)和76.67%(46/60例),试验A、B组分别与对照组比较,差异均有统计学意义(均P0.05),且试验A组和试验B组比较,差异有统计学意义(P0.05)。治疗后,试验A组、试验B组和对照组的UA值分别为(237.31±10.63),(162.67±10.12),(586.52±50.60)μmol·L-1;hs-CRP分别为(4.93±0.68),(3.57±1.03),(12.07±0.54)mg·L-1;IL-6分别为(78.31±10.63),(68.67±10.12),(190.52±50.60)pg·m L-1;IMT分别为(1.08±0.25),(0.76±0.29),(1.42±0.54)mm,差异均有统计学意义(均P0.05)。试验B组的UA、hs-CRP、IL-6及IMT值较试验A组下降更为明显,差异均有统计学意义(均P0.05)。3组患者均未发生明显的药物不良反应。结论苯溴马隆与别嘌醇均能够有效降低急性脑梗死合并高尿酸血症患者的尿酸水平,减轻机体的炎症反应,有效改善动脉粥样硬化的程度,且安全性高,但苯溴马隆的治疗效果更为显著。
[Abstract]:Objective to compare the clinical efficacy and safety of benzene bromide Malone and allopurinol in patients with acute cerebral infarction with hyperuricemia. Methods 180 patients with acute cerebral infarction and hyperuricemia were randomly divided into 60 cases of control group, 60 cases in group A, 60 cases in group B, and 3 groups of patients given cerebral infarction routine treatment. The control group was given placebo (the placebo group). Starch capsules) 25 mg, QD, orally. Group A was given allopurinol 100mg, bid, oral administration. Group B was given benzene bromine Malone 50 mg, QD, and oral.3 group patients were treated with 14 d. to observe the clinical efficacy of 3 groups of patients, blood uric acid (UA), hypersensitivity C reactive protein, carotid intima membrane thickness and adverse drug reaction Results after treatment, the total effective rate of test A group, test group B and control group were 88.33% (53/60 cases), 95% (57/60 cases) and 76.67% (46/60 cases), test A, and B group compared with control group respectively, the difference was statistically significant (P0.05), and the difference was statistically significant (P0.05) compared with the experimental A group and the test B group. After treatment, test In group A, the UA values in group B and control group were (237.31 + 10.63), (162.67 + 10.12) and (586.52 + 50.60) Mu mol. L-1; hs-CRP was (4.93 + 0.68), (3.57 + 1.03), (12.07 + 0.54) mg. L-1, IL-6 (78.31 + 10.63), PG. M L-1, respectively. There were statistical significance (all P0.05). The values of UA, hs-CRP, IL-6 and IMT in group B were more obvious than those in the experimental A group. The difference was statistically significant (all P0.05) group.3 patients had no obvious adverse drug reactions. Conclusion benzene bromide Malone and allopurinol can effectively reduce the level of uric acid in patients with acute cerebral infarction and hyperuricemia, and reduce the level of uric acid in patients with acute cerebral infarction and hyperuricemia. The inflammatory reaction of light body can effectively improve the degree of atherosclerosis, and its safety is high, but the effect of benzbromine Malone is more significant.

【作者单位】：武汉市第三医院神经内科;
【分类号】：R589.7;R743.33

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