利用AMS测量方法研究大鼠的钙吸收率

发布时间：2018-05-10 05:48

本文选题：加速器质谱(AMS) + 内源钙库法　；参考：《质谱学报》2016年02期

【摘要】：钙是人体所必需的元素之一,参与众多的生命生理调控,准确测量生物体的钙吸收率,对于合理补钙和预防钙代谢疾病具有重要意义。本研究采用41 Ca标记SD大鼠体内钙库,利用加速器质谱(AMS)法测量长寿命放射性核素41 Ca灵敏度高的特点,开展对大鼠钙吸收率的准确测定。结果表明:大鼠每100g体重每天摄入28 mg碳酸钙、28 mg柠檬酸钙、10 mg碳酸钙的表观吸收率分别为(67.57±2.79)%、(65.21±2.96)%、(87.50±1.10)%,净吸收率分别为(73.19±3.60)%、(71.47±4.01)%、(92.74±1.81)%。该方法可以得出钙的真实吸收率,且不受所评价的钙剂中钙的化学形式和种类的影响,进一步拓展了同位素评价钙吸收率的应用领域,可为建立适宜于我国人民的钙参考摄入量标准提供实验依据。
[Abstract]:Calcium is one of the essential elements in human body. It is of great significance to take part in many physiological regulation of life and accurately measure the calcium absorption rate of organism for reasonable calcium supplement and prevention of calcium metabolic diseases. In this study, 41 Ca labeled calcium pool in SD rats was used to measure the high sensitivity of long lived radionuclide 41 Ca by means of accelerator mass spectrometry (AMS) method, and the calcium absorption rate of SD rats was determined accurately. The results showed that the apparent absorptivity was 67.57 卤2.79 卤65.21 卤2.96% and 73.19 卤3.6071.47 卤4.01%, respectively. The apparent absorptivity was 73.19 卤3.6071.47 卤4.01 and 92.74 卤1.81, respectively. The real absorption rate of calcium can be obtained by this method, and it is not affected by the chemical form and type of calcium in the calcium agent evaluated, which further expands the application field of isotopic evaluation of calcium absorption rate. It can provide experimental basis for establishing reference intake standard of calcium suitable for Chinese people.
【作者单位】：中国原子能科学研究院核物理研究所;广西师范大学物理科学与技术学院;
【基金】：国家自然科学基金项目(11375272)资助
【分类号】：R580;O657.63

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