沧州地区内陆至沿海迁移人群甲状腺功能异常率及自身抗体阳性率的调查分析

发布时间：2018-05-10 23:20

本文选题：甲状腺疾病 + 甲状腺自身抗体　；参考：《山东医药》2017年25期

【摘要】：目的通过对由沧州地区内陆至沿海迁移人群的甲状腺激素水平和自身抗体的调查分析,探讨迁移人群甲状腺疾病的流行新趋势。方法采用横断面调查,分析由沧州市及沧州市西部县市搬迁至黄骅港10年以上的职工,女782例(女迁移组),男903例(男迁移组)及同期原生活地的职工,女1 050例(女非迁移组),男1 208例(男非迁移组)的甲状腺激素水平和甲状腺自身抗体的阳性率。分析比较女、男迁移组与相应非迁移组间甲状腺功能异常率和自身抗体阳性率的不同;同时抽取各组部分人员给予尿碘测定。对迁移组的部分人员作进一步多因素分析。结果女迁移组甲状腺球蛋白抗体(Tg-Ab)、甲状腺过氧化物酶抗体(TPO-Ab)阳性率明显高于女非迁移组(P均0.01);亚临床甲状腺功能减退(亚甲减)、临床甲状腺功能减退(甲减)的患病率明显高于非迁移组(P均0.05);促甲状腺素受体抗体(TSHRAb)的阳性率、亚临床甲状腺功能亢进(亚甲亢)、临床甲状腺功能亢进(甲亢)的患病率两组间比较未见统计学差异(P均0.05)。男迁移组Tg-Ab、TPO-Ab阳性率明显高于男非迁移组(P均0.05);男迁移组亚甲减患病率明显高于男非迁移组(P0.05);TSHRAb的阳性率和甲减、亚甲亢、甲亢患病率两组间比较,P均0.05。迁移者的尿碘检测值(M=575.5μg/L)明显高于非迁移者(M=370.6μg/L),二者比较,P0.01。甲状腺抗体阳性和功能异常的多因素分析均仅性别一项有统计学意义(P均0.01)。结论沧州地区由内陆至沿海迁移人群甲状腺功能异常率和自身抗体的阳性率均增加,碘摄入增加可能是其部分原因。
[Abstract]:Objective to investigate the level of thyroid hormones and autoantibodies in the migration population from the inland to coastal areas of Cangzhou, and to explore the new epidemic trend of thyroid diseases in the migrating population. Methods A cross-sectional survey was conducted to analyze 782 women (female migration group), male migration group (903 male migration group) and workers living in the same period, who had been relocated to Huanghua port for more than 10 years from Cangzhou and Cangzhou western counties. Thyroid hormone level and positive rate of thyroid autoantibodies in 1 050 women (female non migration group and 1 208 male non migration group). The difference of thyroid function abnormality rate and autoantibody positive rate between female, male migration group and corresponding non-migration group was analyzed. Further multivariate analysis was carried out on some of the people in the migration group. Results the positive rates of thyroglobulin antibody and thyroid peroxidase antibody in female migration group were significantly higher than those in female non-migration group (P 0.01), and the subclinical hypothyroidism (hypothyroidism) and clinical hypothyroidism (hypothyroidism) The prevalence rate of thyrotropin receptor antibody was significantly higher than that of non-migration group (P < 0.05), and the positive rate of thyrotropin receptor antibody (TSHRAb) was significantly higher than that of non-migration group. The prevalence of subclinical hyperthyroidism (subthyroidism) and clinical hyperthyroidism (hyperthyroidism) was not significantly different between the two groups (P < 0.05). The positive rate of Tg-Abn TPO-Ab in male migration group was significantly higher than that in male non-migration group (P 0.05), and the prevalence rate of subthyroidism in male migration group was significantly higher than that in male non-migration group (P 0.05). The prevalence rate of hyperthyroidism, hyperthyroidism and hyperthyroidism were both 0.05 in male migration group. The urinary iodine detection value of emigrants was significantly higher than that of non-migrants (575.5 渭 g / L) and 370.6 渭 g / L / L, respectively (P 0.01). The multivariate analysis of thyroid antibody positive and abnormal function was statistically significant only in sex (P < 0.01). Conclusion the abnormal rate of thyroid function and the positive rate of autoantibodies increased in the migration population from inland to coastal areas in Cangzhou, and the increase of iodine intake may be the reason.
【作者单位】：沧州市中心医院;
【分类号】：R581

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