绝经后女性骨代谢生化指标与骨质疏松性腰椎骨折之间的相关性

发布时间：2018-05-17 20:31

本文选题：绝经后骨质疏松 + 骨质疏松性骨折　；参考：《中国骨质疏松杂志》2017年07期

【摘要】：目的探讨骨代谢标志物对预测绝经后骨质疏松患者合并腰椎骨折风险的诊断价值。方法采用双能X线骨密度仪、酶联免疫检测法(ELISA)和速率法对70例绝经后骨质疏松症腰椎无骨折患者和70例绝经后骨质疏松症腰椎骨折患者的髋部及腰椎骨密度、各项骨代谢生化指标进行检测,并分析骨代谢生化指标的变化与骨质疏松症、骨质疏松性腰椎骨折之间的相关性。结果绝经后骨质疏松性腰椎骨折的发生风险与年龄、体重、身高、体重指数、骨密度等一般指标和骨钙素N端中分子片段(N-MID osteocalcin,N-MID)、骨碱性磷酸酶(bone alkaline phospha,BAP)、钙离子(calcium ionic,Ca~(2+))、骨吸收标志物β-Ⅰ型胶原羧基端肽(β-C-terminal telopeptide of type I collagen,β-CTx)等生化指标之间无关联,而与血清I型原胶原氨基端延长肽(propeptide of type I procollagen,PINP)、抗酒石酸酸性磷酸酶5b(TRAP-5b)和25-羟维生素D(25-hydroxy vitamin,25-(OH)D)之间存在显著相关性(P=0.002、0.007、0.001),其中与PINP、TRAP-5b呈正相关,与25-(OH)D呈负相关。结论绝经后女性血清PINP、TRAP-5b和25-(OH)D与骨质疏松性骨折的发生存在显著的相关性,骨代谢标志物与骨密度的联合检测对预测绝经后骨质疏松腰椎骨折具有一定的临床意义。
[Abstract]:Objective to evaluate the diagnostic value of bone metabolic markers in predicting the risk of lumbar fracture in postmenopausal osteoporosis patients. Methods the bone mineral density of hip and lumbar vertebrae in 70 patients with postmenopausal osteoporosis and 70 patients with postmenopausal osteoporosis were studied by double energy X-ray absorptiometry, Elisa and rate method. The biochemical indexes of bone metabolism were detected and the correlation between the changes of biochemical indexes of bone metabolism and osteoporosis and osteoporotic lumbar fractures was analyzed. Results the risk and age, weight, height, body mass index of postmenopausal osteoporotic lumbar vertebrae fracture, There was no correlation between bone mineral density (BMD) and other biochemical indexes such as N-MID osteocalcinin N-midine, bone alkaline phosphatase bone alkaline phosphaphor, calcium ion calcium ionicionine, bone resorption marker 尾 -C-terminal telopeptide of type I collagen, 尾 -CTx, and so on, and no correlation was found between bone mineral density (BMD) and bone mineral density (BMD) in N-MID osteocalcinin N-MID, bone alkaline phosphatase (BALP), calcium ion calcium ionicionine, 尾 -terminal telopeptide of type I collagen, 尾 -CTx, and so on. But there was a significant correlation between serum procollagen of type I procollagenagenase, tartrate-resistant acid phosphatase (5bAP-5b) and 25-hydroxyvitamin D (25-hydroxyvitamin D) and 25-hydroxyvitamin D (25-hydrovitaminoxy), which was positively correlated with PINPU TRAP-5b and negatively correlated with 25-(OH)D. Conclusion there is a significant correlation between serum PINPU TRAP-5b and 25-(OH)D in postmenopausal women and the occurrence of osteoporotic fractures. The combined detection of bone metabolism markers and bone mineral density has a certain clinical significance in predicting postmenopausal osteoporotic lumbar fractures.
【作者单位】：四平中心医院骨科;内蒙古医科大学附属医院内分泌科;
【分类号】：R580;R683

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