PACG与多发性硬化症的临床关系

发布时间：2018-05-19 04:16

本文选题：原发性闭角型青光眼(PACG) + 多动脉硬化症　；参考：《中国老年学杂志》2017年19期

【摘要】：目的探讨原发性闭角型青光眼(PACG)患者患多发性硬化症(MS)发病率及其关联性。方法对360例PACG患者进行MS筛查,选择年龄、性别等人口学情况相匹配的健康对照者360例作为对照,分析并比较两组MS患者检出情况,分析PACG与多动脉硬化症的相关性。结果 PACG患者中MS患者44例,正常组中MS患者34例9.4%。两组在41~55年龄段MS的发生率有统计学意义(均P0.05);在其他年龄段MS发生率无统计学意义(P0.05)。单因素及多因素分析提示PACG病程、严重程度与年龄、MS病程、MSVQ-7评分、EDSS评分呈正相关(P0.05),与性别、青光眼家族史无相关性(P0.05)。结论 PACG可能与MS的发生相关,临床上监测和控制PACG可为多发性硬化症的预防和治疗治提供依据。
[Abstract]:Objective to investigate the incidence and association of multiple sclerosis (MS) in patients with primary angle-closure glaucoma (PACG). Methods 360 patients with PACG were screened for MS, and 360 healthy controls matched with age, sex and other demographics were selected as controls. The detection of MS in the two groups was analyzed and compared, and the correlation between PACG and polyarteriosclerosis was analyzed. Results there were 44 MS patients in PACG group and 34 MS patients in normal group. The incidence of MS in the 41-55 age group was significantly higher than that in the other age group (P0.05%, P0.05%, P 0.05). Univariate and multivariate analysis showed that the course and severity of PACG were positively correlated with age MS course and MSVQ-7 score and EDSS score, but not with gender and family history of glaucoma. Conclusion PACG may be related to the occurrence of MS. Clinical monitoring and control of PACG may provide evidence for the prevention and treatment of multiple sclerosis.
【作者单位】：南昌大学第一附属医院眼科及神经内科;
【基金】：国家自然科学基金资助项目(No.81160118,81460092,81400372,81660158) 江西省自然科学基金重大项目(No.2016ACB21017);江西省自然科学基金资助项目(No.20151BAB215016) 江西省科技支撑计划项目(No.20151BBG70223) 江西省远航工程(No.2014022)
【分类号】：R744.51

【相似文献】