IL-31及其可溶性受体sOSMR在类风湿关节炎患者血清中表达的研究

发布时间：2018-05-19 03:22

本文选题：类风湿关节炎 + 疾病活动　；参考：《青海大学》2017年硕士论文

【摘要】：目的:本研究通过测定研究对象血清中IL-31及其可溶性受体s OSMR水平,探讨研究IL-31及s OSMR在RA患者疾病活动期的变化,分析其与疾病活动之间的关系,为进一步探讨RA发病机制及其治疗提供新思路。方法:RA组患者43例,按照CDAI评分分为RA低、中、高度活动组。采用ELISA方法测定43例RA患者及23例对照者血清中IL-31、s OSMR水平。分析RA患者血清中IL-31、s OSMR水平与CDAI、ESR、CRP、RF、抗CCP抗体等相关性。结果:⑴RA患者血清中IL-31水平[(53.463±1.984)pg/ml]高于对照组[(27.476±2.846)pg/ml](P0.05),血清中IL-31的水平在RA高度活动组[(81.813±1.898)pg/ml]高于低度活动组[(30.471±1.606)pg/ml]、中度活动组[(47.047±1.764)pg/ml]患者表达水平(均P0.05);RA患者血清中s OSMR水平[(0.357±0.112)ng/ml]与对照组[(0.325±0.065)ng/ml]相比无统计学差异(P0.05),s OSMR在RA低度活动组[(0.299±0.079)ng/ml]、中度活动组[(0.382±0.150)ng/ml]、高度活动组[(0.362±0.068)ng/ml]血清中表达水平无统计学差异(均P0.05)。⑵RA组患者血清中IL-31水平与CDAI、CRP、RF水平呈正相关(r=0.379,r=0.358,r=0.532,均P0.05),与s OSMR、ESR、ACCP均无相关性(均P0.05);RA组患者血清中s OSMR水平与IL-31、CDAI、ESR、CRP、RF、ACCP水平均无相关性(均P0.05)。结论:IL-31可能参与RA疾病发生与发展,并与疾病活动度相关,可作为RA疾病活动评估指标。
[Abstract]:Objective: To explore the changes of IL-31 and s OSMR in the period of disease activity in RA patients by measuring the serum levels of IL-31 and its soluble receptor s OSMR, and to analyze the relationship between them and disease activity, and to provide a new way to further explore the pathogenesis and treatment of RA. Methods: 43 patients in the RA group were divided into RA according to the CDAI score. The serum levels of IL-31 and s OSMR in 43 patients with RA and 23 cases of control were measured by ELISA method. The correlation between IL-31, s OSMR level and CDAI, ESR, CRP, resistance and antibodies in the serum of RA patients was analyzed. The level of IL-31 in the RA high activity group [(81.813 + 1.898) pg/ml] was higher than that in the low activity group [(30.471 + 1.606) pg/ml], and the expression level of the moderate activity group [(47.047 + 1.764) pg/ml]], and the level of s OSMR in the serum of RA patients [(0.357 + 0.112) ng/ml] as that of the control group (0.325 + 0.065) ng/ml] (P0.05). Low activity group [(0.299 + 0.079) ng/ml], moderate activity group [(0.382 + 0.150) ng/ml], high activity group [(0.362 + 0.068) ng/ml], P0.05). The level of IL-31 in the serum of RA group was positively correlated with CDAI, CRP, RF level (r= 0.379, r=0.358, r=0.532, all). 0.05) the serum levels of s OSMR in patients with RA were not related to IL-31, CDAI, ESR, CRP, RF, and ACCP (P0.05). Conclusion: IL-31 may be involved in the occurrence and development of RA disease and related to the degree of disease activity, which can be used as an indicator of disease activity assessment.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.22

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