血清25羟维生素D3水平与老年2型糖尿病周围神经病变相关性研究

发布时间：2018-05-19 10:53

本文选题：25-羟维生素D3 + 周围神经病变　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:研究血清25羟维生素D3[25-hydroxy vitamin D3,25(OH)D3]水平与老年2型糖尿病(type 2 diabetes mellitus,T2DM)周围神经病变的相关性。方法:收集老年T2DM住院患者150例,根据有无合并周围神经病变分为糖尿病合并周围神经病变(Diabetic peripheral neuropathy,DPN)组89例和糖尿病不伴周围神经病变(None diabetic peripheral neuropathy,NDPN)组61例。收集所有患者临床资料,抽取受试者空腹血采用化学发光法检测25(OH)D3水平。结果:DPN组较NDPN组患者维生素D3缺乏发生率分别是88.76%和66.85%,差异有统计学意义(P0.01);DPN组血清25(OH)D3(11.89±6.26)ng/ml低于NDPN组(17.05±6.14)ng/ml,差异有统计学意义(P0.001);DPN组的年龄、病程、FPG、Hb A1C、TC和LDL-C均高于NDPN组,差异有统计学意义(P0.05)。25(OH)D3水平与病程、Hb A1C、UACR呈负相关(P0.05)。Logistic回归分析结果显示:25(OH)D3与DPN的发生呈负相关,是DPN的保护因素,病程和Hb A1C与DPN的发生呈正相关,是DPN的危险因素。结论:25(OH)D3水平下降与老年T2DM伴周围神经病变患者的发生密切相关,补充维生素D是否能延缓DPN进展或缓解DPN患者临床症状仍需进一步探索。
[Abstract]:Objective: to study the relationship between serum 25-hydroxy vitamin D 3 and type 2 diabetes mellitus type 2 diabetes mellitusus T2DM peripheral neuropathy. Methods: one hundred and fifty elderly patients with T2DM were divided into diabetic peripheral neuropathy group (n = 89) and diabetic peripheral neuropathy group (n = 61) according to the presence or absence of peripheral neuropathy. Clinical data of all patients were collected and fasting blood samples were collected to detect 25(OH)D3 level by chemiluminescence. Results the incidence of vitamin D _ 3 deficiency in the NDPN group was 88.76% and 66.85%, respectively. The difference was statistically significant (P < 0.01). The serum 25(OH)D3(11.89 卤6.26)ng/ml was significantly lower than that in the NDPN group (17.05 卤6.14 ng / ml). There was a negative correlation between the level of P0.05OHN D3 and the UACR of HbA1CU. Logistic regression analysis showed that the incidence of DPN was negatively correlated with the incidence of DPN, and was a protective factor of DPN. The course of disease and the occurrence of HB A1C were positively correlated with the occurrence of DPN and the risk factor of DPN. Conclusion the decrease of OH3 level in the aged patients with T2DM with peripheral neuropathy is closely related to the decline of OH3 level. Whether vitamin D supplementation can delay the progression of DPN or alleviate the clinical symptoms of DPN patients should be further explored.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2

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