双膦酸盐预治疗减少首次应用唑来膦酸不良反应的研究

发布时间：2018-05-20 13:19

本文选题：骨质疏松 + 双膦酸盐　；参考：《中国骨质疏松杂志》2017年07期

【摘要】：目的探讨临床中减少唑来膦酸注射液(密固达)不良反应的研究。方法选取我院骨质疏松诊疗基地首次确诊原发性骨质疏松症患者200例,符合世界卫生组织关于骨质疏松症的诊断标准。所有入组患者在口服钙和维生素D基础上随机分为3组,A组为口服阿仑膦酸钠70 mg每周一次,共3个月,3个月后静滴唑来膦酸注射液5 mg;B组为静滴伊班膦酸钠2 mg,3个月后静滴唑来膦酸注射液5 mg;C组为直接静滴唑来膦酸注射液5 mg,其中A、B两组为双膦酸盐预治疗组,观察3组患者首次应用唑来膦酸注射液的不良反应情况。结果所有入组患者中有32%首次应用唑来膦酸注射液出现不同程度的不良反应,主要表现为发热、肌肉酸痛、骨痛等症状,其中A组出现不良反应5例,B组出现不良反应7例,C组出现不良反应52例,3组均未出现腹泻、皮疹、心律失常及肝肾功能损害,将3组数据进行统计学分析,双膦酸盐预治疗组(A组和B组)首次应用唑来膦酸注射液所发生的不良反应明显比C组少,且差异具有统计学意义;A组和B组之间的不良反应差异不具有统计学意义。结论在骨质疏松症的临床治疗中,双膦酸盐预治疗能减少首次应用唑来膦酸注射液不良反应的发生,进一步提高患者依从性。
[Abstract]:Objective to study the reduction of adverse reactions of zoledronic acid injection (Mecuta) in clinic. Methods 200 patients with primary osteoporosis were selected for the first time in our hospital, which were in accordance with the World Health Organization (WHO) criteria for the diagnosis of osteoporosis. All the patients were randomly divided into three groups on the basis of oral calcium and vitamin D: oral alendronate 70 mg once a week. After 3 months, 5 mg of zoledronic acid injection was given by intravenous drip, 2 mg of ibandronate sodium was given in group B, and 5 mg of azoledronic acid injection was used in group C 3 months later. The adverse reactions of zoledronic acid injection were observed in 3 groups for the first time. Results 32% of the patients were treated with zoledronic acid for the first time. The main symptoms were fever, muscle soreness, bone pain and so on. There were 5 cases of adverse reactions in group A, 7 cases in group C, 52 cases in group C, no diarrhea, rash, arrhythmia and damage of liver and kidney function. The adverse effects of zoledronic acid injection in group A and group B were significantly lower than those in group C, and there was no significant difference in adverse reactions between group A and group B. Conclusion in the clinical treatment of osteoporosis, bisphosphonate pretreatment can reduce the occurrence of adverse reactions of zoledronic acid injection for the first time, and further improve the compliance of patients.
【作者单位】：哈尔滨医科大学附属第二医院老年病科;
【分类号】：R580

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