不同性别甲状腺功能正常人群促甲状腺素与代谢综合征的相关性分析

发布时间：2018-05-21 08:10

本文选题：促甲状腺素 + 代谢综合征　；参考：《南京医科大学学报(自然科学版)》2017年05期

【摘要】：目的:探讨不同性别甲状腺功能正常人群促甲状腺素(TSH)与代谢综合征(MS)的关系,为防治提供临床依据。方法 :采用横断面研究,选取甲状腺功能正常者10 842例,男7 250例,女3 592例,测量身高、体重、血糖、收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、尿素氮(BUN)、肌酐(SCr)及甲状腺功能,计算体重指数(BMI)及预估肾小球滤过率(eGFR),分析TSH与MS的关系。结果:男、女MS患病率分别为20.1%、9.4%,MS组TSH水平均显著高于非MS组(男P=0.049,女P=0.009)。不同性别人群的TSH按四分位数分组,随着TSH的增加,MS的患病率升高,且符合MS诊断标准的项目数也显著增加(男P=0.05,女P0.01)。在男性TSH,与年龄、SBP、UA、TG、SCr呈正相关,与HDL-C、eGFR呈负相关;在女性,TSH与年龄、SBP、DBP、UA、TG、LDL-C、TC、SCr、BMI呈正相关,与HDL-C、eGFR呈负相关。Logistic回归分析,校正年龄、尿酸、血糖、血脂后,男性TSH是MS的独立危险因素(P=0.043)。结论:在甲状腺功能正常的人群,尤其是男性人群中,TSH水平升高可能增加MS的患病风险,进而增加心血管疾病的发生风险。
[Abstract]:Objective: to investigate the relationship between thyrotropin TSHs and metabolic syndrome (MSS) in healthy people with different sex thyroid function, and to provide clinical basis for prevention and treatment. Methods: a cross-sectional study was conducted in 10 842 patients with normal thyroid function, including 7 250 males and 3 592 females. Height, weight and blood glucose were measured. Systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), UAA, urea nitrogen (bun), creatinine (SCR), and thyroid function. Body mass index (BMI) and glomerular filtration rate (GFR) were calculated and the relationship between TSH and MS was analyzed. Results: the TSH level in MS group was significantly higher than that in non-MS group (P < 0.049 for male and 0.009 for female). With the increase of TSH, the prevalence of MS increased, and the number of items that met the diagnostic criteria of MS also increased significantly (P0. 05 for males and P0. 01 for females. In male, TSH was positively correlated with age SBP UAA TGG / SCr, and negatively correlated with HDL-Cngfr, in female, TSH was positively correlated with age and age of TGLDL-CU TGLDL-CfU, and negatively correlated with age, uric acid, blood sugar and serum lipids, male TSH was an independent risk factor for MS (P 0.043). Conclusion: the elevated level of TSH may increase the risk of MS and increase the risk of cardiovascular disease in people with normal thyroid function, especially in men.
【作者单位】：江苏省省级机关医院内分泌科;
【基金】：国家自然科学基金面上项目(71373132)
【分类号】：R589

【相似文献】