老年2型糖尿病合并低T3综合征与血8-异前列腺素F2α水平的相关性

发布时间：2018-05-23 12:20

本文选题：型糖尿病 + -异前列腺素Fα　；参考：《中国老年学杂志》2016年22期

【摘要】：目的通过8-异前列腺素F2α(8-iso-PGF)2α探讨老年2型糖尿病合并低T3综合征与氧化应激的关系。方法新诊断老年2型糖尿病患者167例,分为单纯糖尿病组85例和糖尿病合并低T3综合征组82例,同时选取健康体检者80例作为对照组。检测游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、8-iso-PGF2α、糖化血红蛋白(Hb A1c)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果各组间年龄、体重指数(BMI)、TC、FT4、TSH差异无统计学意义(P0.05);单纯糖尿病组、糖尿病合并低T3综合征组8-iso-PGF2α、HBA1c、TG、HDL-C、LDL-C均高于健康对照组,FT3低于健康对照组(P0.05)。进一步进行多元逐步回归分析显示,年龄、8-iso-PGF2α是影响2型糖尿病发生低T3综合征的重要因素(B=-0.023、-0.005;P=0.028、0.000)。结论氧化应激可能与2型糖尿病患者发生低T3综合征有关。
[Abstract]:Objective to investigate the relationship between oxidative stress and type 2 diabetes mellitus in elderly patients with low T3 syndrome through 8-iso-PGF2 伪 -isoprostaglandin F _ 2 伪. Methods 167 newly diagnosed elderly patients with type 2 diabetes were divided into simple diabetes group (n = 85) and diabetes with low T3 syndrome group (n = 82). 80 healthy persons were selected as control group. Free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin (TSHN) 8-iso-PGF2 伪, glycosylated hemoglobin (HbA1cN), triglyceride (TGN), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) were detected. Results there was no significant difference in age and body mass index (BMI) between the two groups (P 0.05), and the 8-iso-PGF2 伪 HBA1cTGG HDL-Cn LDL-C in diabetes mellitus with low T3 syndrome was significantly higher than that in healthy control group (P 0.05). Further multivariate stepwise regression analysis showed that the age of 8-iso-PGF2 伪 was an important factor affecting the occurrence of low T3 syndrome in type 2 diabetes mellitus. Conclusion oxidative stress may be associated with low T 3 syndrome in patients with type 2 diabetes.
【作者单位】：潍坊市人民医院内分泌科;潍坊市妇幼保健院门诊部;
【基金】：潍坊市卫生计生委项目计划〔第2013010号〕
【分类号】：R587.1

【相似文献】