血清肥大细胞羧肽酶与支气管哮喘的相关性研究

发布时间：2018-05-25 11:09

本文选题：支气管哮喘 + 肥大细胞羧肽酶　；参考：《中国免疫学杂志》2017年11期

【摘要】：目的:检测支气管哮喘患者外周血中肥大细胞羧肽酶的含量,研究其与哮喘患者FEV 1(%)、IgE的关系,探讨其在支气管哮喘发病机制中的作用。方法:35例临床确诊为中重度持续性支气管哮喘患者作为病例组,均行肺功能及IgE水平检测,依据血清IgE水平将支气管哮喘患者分为IgE升高组(n=20)和IgE正常(n=15)。另外,选取22名健康者作为对照组,采用ELISA法检测受试者血清肥大细胞羧肽酶水平。比较支气管哮喘患者与健康者血清中肥大细胞羧肽酶水平;分析血清肥大细胞羧肽酶水平与IgE及肺功能的相关性。结果:IgE升高组患者血清肥大细胞羧肽酶水平明显高于IgE正常组(P0.05);支气管哮喘急性发作期患者血清肥大细胞羧肽酶水平明显高于健康对照组(P0.05);另外,哮喘急性发作期患者血清肥大细胞羧肽酶水平与患者FEV(%)呈明显的负相关;缓解期血清肥大细胞羧肽酶水平与FEV1(%)无相关性(r=-0.421,P=0.012;r=-0.284,P=0.099)。结论:血清肥大细胞羧肽酶可能参与了支气管哮喘急性发作的气道炎症反应。
[Abstract]:Aim: to study the relationship between FEV _ 1 and the level of mast cell carboxypeptidase in the peripheral blood of asthmatic patients, and to explore its role in the pathogenesis of bronchial asthma. Methods 35 patients with moderate and severe persistent bronchial asthma were selected as the case group. Lung function and IgE level were measured. According to the serum IgE level, bronchial asthma patients were divided into two groups: IgE elevated group (n = 20) and IgE normal group (n = 15). In addition, ELISA assay was used to detect the carboxypeptidase level of mast cells in 22 healthy controls. To compare the level of mast cell carboxypeptidase in patients with bronchial asthma and healthy subjects, and to analyze the correlation between the level of serum mast cell carboxypeptidase and IgE and pulmonary function. Results the level of mast cell carboxypeptidase in patients with elevated IgE was significantly higher than that in patients with normal IgE, while the level of carboxypeptidase in patients with acute asthma attack was significantly higher than that in healthy controls. There was a significant negative correlation between serum mast cell carboxypeptidase level and FEV1 level in patients with acute asthma attack, but no correlation between serum mast cell carboxypeptidase level and FEV1 level in remission phase. Conclusion: serum mast cell carboxypeptidase may be involved in airway inflammation in acute attack of bronchial asthma.
【作者单位】：吉林大学第一医院;内蒙古民族大学附属医院;
【分类号】：R562.25

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