2型糖尿病患者肺功能改变及其影响因素分析

发布时间：2018-05-26 00:48

本文选题：2型糖尿病 + 肺功能　；参考：《宁夏医科大学》2015年硕士论文

【摘要】：目的探讨2型糖尿病患者肺功能改变及其影响因素。方法以符合入选标准的2型糖尿病患者为2型糖尿病组(100例),测定各项肺功能指标及空腹血糖、血脂、BMI、糖化血红蛋白等实验室检查以及尿微量白蛋白、眼底照相、神经电图检查,计算胰岛素抵抗指数、吸烟指数,以无糖尿病的健康人群为对照组(40例),比较两组肺功能变化,并对糖尿病组肺功能变化的影响因素进行相关性分析。结果2型糖尿病组的TLC、VC,FEV1、MEF25、MEF50均低于健康对照组,FEV1/FVC高于对照组,两组比较差异有统计学意义(P0.05),对糖尿病组进行相关性分析,TLC、VC、DLCO、DLCO/VA与病程、Hb A1C、BMI、HOMA-IR、FPG及并发症积分呈负相关,MVV与BMI及微血管并发症呈负相关,FEV1与Hb A1C、BMI、HOMA-IR、FPG、并发症积分呈负相关,FEV1/FVC与BMI及并发症积分呈正相关,MEF25与病程、BMI、HOMA-IR、并发症积分呈负相关,MEF50与病程、Hb A1C、BMI、HOMA-IR呈负相关。结论2型糖尿病患者存在肺功能损害,以限制性通气功能障碍、小气道功能及弥散功能减退为主,肺脏病变可能是糖尿病慢性并发症之一,糖尿病病程、血糖水平、胰岛素抵抗程度、BMI与肺损伤密切相关,控制血糖、改善胰岛素抵抗、控制体重对防治肺损伤有重要意义。
[Abstract]:Objective to investigate the changes of pulmonary function and its influencing factors in type 2 diabetes mellitus. Methods 100 patients with type 2 diabetes mellitus were enrolled in this study. The pulmonary function indexes, fasting blood glucose, serum lipids and BMIs, glycosylated hemoglobin, urine microalbumin and fundus photography were measured. The indexes of insulin resistance and smoking were calculated by electroencephalogram, and 40 cases of control group were taken as control group. The changes of pulmonary function were compared between the two groups, and the influencing factors of pulmonary function in diabetic group were analyzed. Results in type 2 diabetes group, the level of TLCV 1 / FEV1 MEF25 MEF50 was lower than that of the healthy control group (FEV 1 / FVC), and the level of FEV 1 / FVC was higher than that of the control group. There was a significant difference between the two groups (P 0.05). The correlation between TLCV and DLCOP / VA was negatively correlated with the course of disease HbA1CU BMIMA-IRFPG and the score of complications. There was a negative correlation between MV1 and BMI and microvascular complications. The correlation between FEV1 and HbA1CMIBMIHOMA-IRFPGand complication score was negative correlation between FEV1 / FVC and FVC. There was a positive correlation between MEF25 and BMI-HOMA-IR.There was a negative correlation between MEF50 and BMI-HOMA-IR, and a negative correlation between MEF50 and BMI-HOMA-IR. Conclusion Type 2 diabetes mellitus patients have pulmonary function impairment, mainly restricted ventilation dysfunction, small airway function and diffusion function decline. Pulmonary lesions may be one of the chronic complications of diabetes mellitus, the course of diabetes mellitus, blood glucose level. The degree of insulin resistance and BMI are closely related to lung injury. It is important to control blood glucose, improve insulin resistance and control body weight to prevent lung injury.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1

【相似文献】