限能量平衡膳食对超重或肥胖多囊卵巢综合征患者体成分和代谢影响研究

发布时间：2018-05-31 00:36

本文选题：限能量平衡膳食 + 超重或肥胖多囊卵巢综合征　；参考：《中国实用内科杂志》2017年05期

【摘要】：目的回顾性分析限能量平衡膳食(CRD)对超重或肥胖多囊卵巢综合征(PCOS)患者体成分和代谢指标的影响。方法回顾分析南京大学医学院附属鼓楼医院收治的59例体重指数(BMI)≥24的PCOS经CRD干预前后的数据,测定了体成分、血脂、75 g口服葡萄糖耐量实验和同步胰岛素释放试验,并计算稳态模型评估胰岛素抵抗指数(HOMA-IR)。采用配对t检验和McNemar卡方检验比较分析。结果经12周干预,患者体重下降(7.21±3.76)kg(9.05%),体脂肪(BF)、体脂百分比(BFP)和内脏脂肪面积(VFA)分别下降16.15%、8.00%和12.59%,腰围(WC)减少(7.00±4.12)cm(6.96%)、腰臀比(WHR)下降3.16%(P均0.001);总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、胰岛素0 min和120 min均显著下降(P均0.05)。胰岛素抵抗(IR,定义为HOMA-IR≥2.69)检出率由干预前89.83%降至干预后54.55%,代谢综合征(MS)的检出率由干预前67.80%降至干预后42.37%。结论超重或肥胖PCOS患者经CRD干预可以减轻体重、BF、VFA,并改善脂代谢紊乱、IR和MS。
[Abstract]:Objective to analyze the effects of energy limited balanced diet (CRD) on body composition and metabolic indexes of overweight or obese polycystic ovary syndrome (PCOS). Methods the data of 59 cases of PCOS with CRD or more than 24 of body mass index (BMI) in the Affiliated Drum Tower Hospital of Nanjing University medical college were analyzed. The body composition, blood lipid, and 75 g oral Portuguese were measured. The glucose tolerance test and simultaneous insulin release test were used to evaluate the insulin resistance index (HOMA-IR). The paired t test and the McNemar chi square test were used to compare the results. The results showed that the weight loss (7.21 + 3.76) kg (9.05%), body fat (BF), body fat percentage (BFP) and visceral fat area (VFA) decreased by 16.15 after 12 weeks of intervention. %, 8% and 12.59%, WC decreased (7 + 4.12) cm (6.96%), waist to hip ratio (WHR) decreased 3.16% (P 0.001); total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), three glycerol (TG), insulin 0 min and 120 min (P mean 0.05). Insulin resistance (IR, HOMA-IR > 2.69) was reduced from 89.83% before intervention to intervention after intervention. 55%, the detection rate of metabolic syndrome (MS) was reduced from 67.80% to intervention before intervention and 42.37%. conclusion overweight or obese PCOS patients with CRD intervention can reduce weight, BF, VFA, and improve lipid metabolism disorders, IR and MS.
【作者单位】：南京大学医学院附属鼓楼医院;北京协和医院;
【基金】：南京市卫生局科技发展项目(YKK13075)
【分类号】：R711.75

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