糖尿病足部溃疡感染病原菌特点及相关因素分析

发布时间：2018-05-31 13:38

本文选题：糖尿病 + 足部溃疡　；参考：《中国感染与化疗杂志》2017年01期

【摘要】：目的探讨糖尿病足部溃疡感染病原菌的特点以及相关危险因素,并针对相关因素提出预防及干预措施,以促进患者早日康复。方法回顾性分析2012年2月至2014年5月治疗的120例糖尿病足患者临床资料,将发生糖尿病足部溃疡感染的38例患者作为感染组,未发生溃疡感染的82例患者作为非感染组,分析糖尿病足部溃疡感染的病原菌特点和影响感染相关危险因素。结果该研究38例感染患者中共分离出病原菌43株,革兰阳性菌22株,占51.2%;革兰阴性菌18株,占41.9%;真菌3株,占7.0%。位居前3的病原菌为金黄色葡萄球菌、铜绿假单胞菌和阴沟肠杆菌,均为7株,各占16.3%。单因素分析结果显示,合并糖尿病血管并发症、合并视网膜病变、溃疡数目2个、合并骨髓炎以及合并肾病等与感染密切相关(P0.05);多因素分析结果显示,高密度脂蛋白胆固醇、血红蛋白、糖尿病血管并发症以及溃疡数目、骨髓炎是糖尿病足部溃疡感染的独立危险因素。结论糖尿病足部溃疡感染是多种因素共同作用而致,因此临床应加强对这些因素的预防和控制,以降低糖尿病足部溃疡的感染率。
[Abstract]:Objective to investigate the characteristics of pathogenic bacteria of diabetic foot ulcer infection and the related risk factors, and to put forward prevention and intervention measures to promote the early recovery of patients with diabetic foot ulcers. Methods the clinical data of 120 diabetic foot patients treated from February 2012 to May 2014 were retrospectively analyzed. 38 patients with diabetic foot ulcer infection and 82 patients without ulcer infection were selected as infection group. To analyze the pathogenic bacteria characteristics of diabetic foot ulcer infection and the risk factors related to infection. Results A total of 43 pathogenic bacteria were isolated from 38 infected patients, 22 Gram-positive bacteria (51.2%), 18 Gram-negative bacteria (41.9%) and 3 fungi (7.0%). The first 3 pathogens were Staphylococcus aureus, Pseudomonas aeruginosa and Enterobacter cloacae. Univariate analysis showed that the number of diabetic vascular complications, retinopathy, ulcers, osteomyelitis and nephropathy were closely related to infection (P 0.05). Hemoglobin, diabetic vascular complications and number of ulcers, osteomyelitis are independent risk factors for diabetic foot ulcer infection. Conclusion the infection of diabetic foot ulcers is caused by many factors, so the prevention and control of these factors should be strengthened in order to reduce the infection rate of diabetic foot ulcers.
【作者单位】：中山大学附属第五医院干部保健科;中山大学附属第五医院预防保健科;中山大学附属第五医院消化科;
【分类号】：R587.2

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