知柏地黄丸对糖尿病前期阴虚燥热证人群干预的临床研究

发布时间：2018-06-01 04:17

本文选题：糖尿病前期 + 知柏地黄丸　；参考：《中国中西医结合杂志》2017年11期

【摘要】：目的观察知柏地黄丸干预糖尿病前期人群(阴虚燥热证)的临床效果。方法 260例辨证为阴虚燥热证糖尿病前期患者,随机分为知柏地黄丸治疗组(130例)及对照组(130例)。观察结束共脱落及剔除病例39例,纳入统计治疗组108例,对照组113例。两组均进行健康教育及一般生活方式干预,治疗组在此基础上给予知柏地黄丸8粒,每日2次口服;共治疗12个月后,观察两组患者体重(Wt)、体重指数(BMI)、腰围(Wc)、空腹血糖(FPG)、口服75g葡萄糖后2h血糖(2hPG)、糖化血红蛋白A1c(HbA1c)、TG、TC、中医症状积分,计算糖尿病转化率、转正常率及糖调节受损(IGR)稳定率。结果与对照组比较,治疗组糖尿病转化率降低(P0.01),IGR稳定率升高(P0.05)。两组转正常率比较,差异无统计学意义(P0.05)。与本组治疗前比较,两组FPG、2hPG、HbA1c、TG、TC、Wt、BMI、Wc水平及中医症状积分均降低(P0.05,P0.01);与对照组同期比较,治疗后治疗组FPG、2hPG、HbA1c、TG、Wc水平及中医症状积分降低(P0.05,P0.01)。治疗前后两组患者的肝肾功能、心电图指标比较,差异无统计学意义(P0.05)。结论知柏地黄丸能降低糖尿病前期人群(阴虚燥热证)的FPG、2hPG、HbA1c、TG、WC,减轻临床症状,延缓糖尿病的发生。
[Abstract]:Objective to observe the clinical effect of Zhibai Dihuang Pill (Zhibai Dihuang Pill) on the pre-diabetic population (Yin deficiency, dryness and heat syndrome). Methods 260 cases of pre-diabetic patients with syndrome differentiation of yin deficiency, dryness and heat were randomly divided into treatment group (n = 130) and control group (n = 130). 39 cases of abscission and elimination were observed, 108 cases in the statistical treatment group and 113 cases in the control group. Both groups were given health education and general lifestyle intervention. On this basis, the treatment group was given 8 tablets of Zhibodihuang pills, twice a day, after 12 months of treatment, The body weight, body mass index (BMI), waist circumference (WCC), fasting blood glucose (FBG) FPGN, 2 h blood glucose (2h PGN), glycosylated hemoglobin A1cHbA1cA1C (TGG) TCc, diabetes conversion rate, normal rate and IGR stability rate were observed in both groups. Results compared with the control group, the conversion rate of diabetes decreased and the stable rate of IGR increased in the treatment group. There was no significant difference in normal rate between the two groups (P 0.05). Compared with those before treatment, the level of TGN TCtBMIWc and the score of TCM symptoms decreased in the two groups, compared with the control group, the level of 2hPGA1hPGA1hPGA1cTGWc and the score of TCM symptoms in the treatment group decreased P0.05U / P0.01and P0.01a respectively, compared with that of the control group in the same period, the level of HbA1cTGWc and the score of TCM symptom were decreased in the treatment group. There was no significant difference in liver and kidney function and electrocardiogram between the two groups before and after treatment (P 0.05). Conclusion Zhibaidihuang pills can reduce the level of FPG2 hPGA1cTGG WCin the pre-diabetic population (Yin deficiency and heat syndrome), alleviate the clinical symptoms and delay the onset of diabetes mellitus.
【作者单位】：山东省青岛市海慈医疗集团内分泌科;
【基金】：青岛市卫生局2012年度中医科研计划项目(No.2012-zyz002)
【分类号】：R587.1

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