夏枯草颗粒联合甲巯咪唑对Graves病患者自身抗体及细胞因子的影响

发布时间：2018-06-01 13:41

本文选题：夏枯草颗粒 + 甲巯咪唑　；参考：《基因组学与应用生物学》2017年09期

【摘要】：探讨夏枯草颗粒联合甲巯咪唑对毒性弥漫性甲状腺肿(Graves病,GD)患者自身抗体及细胞因子的影响。选取GD患者80例为研究对象,随机分为观察组和对照组,2组均给予高热量、高维生素、低碘等基础治疗,对照组口服甲巯咪唑片10 mg/次,3次/d,根据病情可适当调整剂量15~40 mg/d,观察组在对照组基础上联合夏枯草颗粒1袋/次,2次/d,2组治疗12周后进行疗效评价。2组采集治疗前后清晨空腹外周静脉血,采用电化学发光分析仪测定血清游离三碘甲状腺原氨酸(FT_3)、游离甲状腺素(FT_4)、促甲状腺素(TSH)水平及抗甲状腺球蛋白抗体(TGAb)、促甲状腺素受体抗体(TRAb)、抗甲状腺微粒体抗体(TMAb)水平,放射免疫法测定过氧化物酶抗体(TPOAb)水平;ELISA法测定肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、干扰素-γ(IFN-γ)水平。研究发现治疗后观察组FT_3、FT_4明显低于对照组,TSH较对照组明显升高(p0.05);治疗后观察组TGAb、TPOAb、TMAb显著低于对照组(p0.05);观察组治疗后TNF-α显著低于对照组,IL-10显著高于对照组(p0.05),而IL-6、IFN-γ无明显差异(p0.05)。表明夏枯草颗粒联合甲巯咪唑可有效降低GD患者自身抗体水平,调节异常免疫功能,减轻炎性反应,改善甲状腺功能。
[Abstract]:To investigate the effect of Prunella subtilis granules combined with methimazole on autoantibodies and cytokines in patients with toxic diffuse goiter Graves disease. Eighty patients with GD were randomly divided into two groups: the observation group and the control group were treated with high calorie, high vitamin, low iodine and so on. The control group was given methimazole tablets for 10 mg/ 3 / d, and the dosage of 1540 mg / d could be adjusted according to the condition of the disease. The observation group was treated with 1 bag of Prunella solani granules / 2 times per day for 12 weeks. Before and after treatment, fasting peripheral venous blood, The levels of serum free triiodothyronine (FT3), free thyroxine triiodothyronine (FT3), thyrotropin (TSH), thyroglobulin (TGA), thyrotropin receptor (TRAbn) and antithyroid microsomal antibody (TMAbb) were measured by electrochemiluminescence analyzer. Radioimmunoassay was used to determine the level of peroxidase antibody (TPOAb). Elisa was used to detect the levels of tumor necrosis factor- 伪 (TNF- 伪), interleukin-6 (IL-6), interleukin-10 (IL-10) and interferon- 纬 (IFN- 纬). It was found that the levels of TSH in the observation group were significantly lower than those in the control group (P 0.05), that in the observation group was significantly lower than that in the control group (p 0.05), and that in the observation group the level of TNF- 伪 was significantly lower than that in the control group (p 0.05), while the level of IL-6 IFN- 纬 in the observation group was not significantly different from that in the control group (P 0.05). The results showed that Prunella vulgaris granules combined with methimazole could effectively reduce the level of autoantibodies, regulate abnormal immune function, alleviate inflammatory reaction and improve thyroid function in patients with GD.
【作者单位】：张家口学院医学基础部;张家口学院护理学院;
【基金】：河北省高等教育学会“十二五”高等教育科学研究课题项目(GJXH2011-41)资助
【分类号】：R581

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