克罗米芬联合地塞米松治疗多囊卵巢综合征疗效观察

发布时间：2018-06-01 15:22

本文选题：多囊卵巢综合征 + 克罗米芬　；参考：《山东医药》2017年20期

【摘要】：目的探讨克罗米芬联合地塞米松对多囊卵巢综合征(PCOS)的治疗效果。方法选取PCOS患者120例,随机分为观察组和对照组各60例。两组均于月经后第5天连续5天口服克罗米芬(50 mg/d),观察组月经周期第1天口服地塞米松(1片/次,1次/d),连续15天;两组均治疗3个月。统计治疗3个月内两组不良反应发生情况及排卵率、妊娠率;分别于治疗前后检测血清卵泡刺激素(FSH)、促黄体生成素(LH)、睾酮(T)、雌二醇(E2)、胰岛素(INS),卵泡液IL-6、TNF-α、IL-1β及总抗氧化能力(TAC)和超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPx)、谷氨酸半胱氨酸连接酶(Gcl-c)。结果观察组排卵率及妊娠率均高于对照组(P均0.05),两组不良反应发生率比较差异无统计学意义(P0.05)。两组治疗后血清FSH、LH、T、E2、INS水平均较治疗前降低(P均0.05)。治疗后两组TAC、SOD、GPx均升高,卵泡液IL-6、TNF-α、IL-1β均降低,但观察组变化更显著(P均0.05)。两组治疗前后CAT、Gcl-c比较P均0.05。结论克罗米芬联合地塞米松可促进PCOS患者排卵及妊娠,且效果好于单用克罗米芬。
[Abstract]:Objective to investigate the therapeutic effect of clomiphene combined with dexamethasone on polycystic ovary syndrome (PCOS). Methods 120 patients with PCOS were randomly divided into observation group (n = 60) and control group (n = 60). In both groups, clomiphene 50 mg / d was given orally for 5 days after menstruation, and dexamethasone was given orally for 15 days on the first day of menstrual cycle in the observation group, and the two groups were treated for 3 months. The incidence of adverse reactions, ovulation rate and pregnancy rate in the two groups were statistically analyzed within 3 months. Serum follicle stimulating hormone (FSH), luteinizing hormone (LHN), testosterone (TX), estradiol (E2P), insulin (INSN), IL-6TNF- 伪 (IL-1 尾), superoxide dismutase (SOD), catalase (CAT), glutathione peroxides (GSH) were detected before and after treatment. Glutamic acid cysteine ligase Gcl-c. Results the ovulation rate and pregnancy rate in the observation group were higher than those in the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). After treatment, the serum levels of FSHLHN, THX, E2 and ins in both groups were lower than those before treatment (P < 0.05). After treatment, the levels of tact SOD GPX in both groups were increased, and IL-6 TNF- 伪 IL-1 尾 was decreased in follicular fluid, but the changes in observation group were more significant than those in control group (P < 0.05). The comparison of Gcl-c between the two groups before and after treatment (P < 0.05). Conclusion clomiphene combined with dexamethasone can promote ovulation and pregnancy in patients with PCOS, and the effect is better than that of clomiphene alone.
【作者单位】：海口市妇幼保健院;
【基金】：海南省自然科学基金项目(20158312)
【分类号】：R711.75

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