绝经后骨质疏松症患者血清TRACP-56、Hcy、BAP水平变化及诊断效能

发布时间：2018-06-03 07:02

本文选题：绝经后骨质疏松症 + 抗酒石酸酸性磷酸酶-b　；参考：《山东医药》2017年35期

【摘要】：目的观察绝经后骨质疏松症(PMOP)患者血清抗酒石酸酸性磷酸酶-5b(TRACP-5b)、同型半胱氨酸(Hcy)、骨源性碱性磷酸酶(BAP)水平变化,并探讨其临床意义。方法将138例绝经后女性按骨密检查结果分为PMOP组(骨密度低于-2.5)39例、骨密度降低组(骨密度-2.5~-1.0)51例、骨密度正常组(骨密度-1.0~1.0)48例。检测各组血清TRACP-5b、Hcy、BAP水平,采用偏相关性分析法分析PMOP组患者血清TRACP-5b、Hcy、BAP水平的相关性。绘制血清TRACP-5b、Hcy、BAP水平诊断PMOP的受试者工作曲线(ROC曲线),计算曲线下面积,采用最大约登指数法确定血清TRACP-5b、Hcy、BAP水平诊断PMOP的截断值。结果 PMOP组血清TRACP-5b、Hcy、BAP水平均高于骨密度降低组和骨密度正常组(P均0.05),骨密度降低组血清TRACP-5b、Hcy、BAP水平均高于骨密度正常组(P均0.05)。偏相关分析结果显示观察组血清Hcy水平与血清TRACP-5b水平呈正相关(r=0.728,P0.05),与血清BAP水平呈正相关(r=0.691,P0.05);血清TRACP-5b水平与血清BAP水平呈正相关(r=0.653,P0.05)。血清TRACP-5b、Hcy、BAP水平诊断PMOP的ROC曲线下面积分别为0.728、0.717、0.695,截断值分别为3.43 U/L、17.85μg/L、23.38 mmol/L。结论 PMOP患者血清TRACP-5b、BAP、Hcy水平升高。临床上可以用血清TRACP-5b、BAP、Hcy辅助诊断PMOP。
[Abstract]:Objective to observe the changes of serum antitartrate acid phosphatase -5bAP-5b, homocysteine, bone alkaline phosphatase (BAP) in patients with postmenopausal osteoporosis (PMOP) and to explore its clinical significance. Methods according to bone density, 138 postmenopausal women were divided into PMOP group (BMD < -2.5), BMD decreased group (BMD -2.5 + -1.0) and normal BMD group (BMD -1.0) in 48 cases. The levels of serum TRACP-5bHcyAP-BAP were detected in each group, and the correlation of serum TRACP-5bHcyAP-BAP levels in patients with PMOP was analyzed by partial correlation analysis. The operating curve of PMOP was drawn and the area under the curve was calculated. The truncation value of serum TRACP-5 BAP for diagnosis of PMOP was determined by the method of maximum Jordan index. Results the serum levels of TRACP-5bHcyhcyBAP in PMOP group were higher than those in BMD decreased group and normal BMD group (P 0.05), and the levels of serum TRACP-5 BAP in BMD decreased group were higher than those in BMD normal group (P 0.05). The results of partial correlation analysis showed that the serum Hcy level was positively correlated with the serum TRACP-5b level, the serum BAP level was positively correlated with the serum BAP level, and the serum TRACP-5b level was positively correlated with the serum BAP level. The area under the ROC curve of serum TRACP-5 BAP for PMOP diagnosis was 0.728 / 0.717 / 0.695, and the truncation value was 3.43 U / L / L 17.85 渭 g / L ~ (23.38) mmol 路L ~ (-1) 路L ~ (-1), respectively. Conclusion the level of serum TRACP-5 BAPP Hcy in patients with PMOP is increased. Serum TRACP-5 BAPHcy can be used to assist the diagnosis of PMOP.
【作者单位】：贵州省骨科医院;
【基金】：贵州省卫生厅科研计划项目(201510003524)
【分类号】：R580

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