从络病立论防治糖尿病周围神经病变优化方案的研究

发布时间：2018-06-05 07:50

本文选题：从络病立论 + 经验方益气活络汤　；参考：《山东中医药大学》2015年硕士论文

【摘要】：目的:观察从络病立论防治糖尿病周围神经病的临床疗效,比较应用经验方益气活络汤联合甲钴胺注射液500ug皮下注射,较单纯应用甲钴胺注射液500ug皮下注射治疗糖尿病周围神经病的优势。方法:120例患者据其病史、症状、体征,诊断为糖尿病周围神经病变,符合入选的标准,随机分治疗组60例,对照组60例,两组的年龄、性别、病程血糖、糖化血红蛋白、及糖尿病周围神经病变症状、体征,经统计学分析,P0.05,无显著差异,有可比性。因患者病史较长,两组均给予患者门冬胰岛素30(由诺和诺德中国制药有限公司生产),分早晚皮下注射胰岛素的方法控制血糖,并根据血糖水平酌情调整降糖药物剂量。对照组给予甲钴胺注射液500ug皮下注射,每日1次。治疗组在对照组的基础上口服益气活络汤,每日1剂,水煎300ml,分早晚两次温服,疗程4周。煎药有我院煎药室免费代煎。疗程结束观察2组临床疗效,进行统计学分析。结果:①据症状、体征及积分改善进行比较:治疗组总有效率86.67%,对照组总有效率63.33%。②感觉神经传导速度(SCV)及运动神经传导速度(MCV)治疗前后比较:组内比较,治疗组*P0.01,对照组▲P0.05;组间比较,治疗组优于对照组△P0.01。③两组症状积分治疗前后比较,组内比较,两组P0.05,组间比较,治疗组优于对照组P0.05。④血糖治疗前后变化比较:组内比较P0.05;组间比较,治疗组优于对照组▲P0.05。⑤应用经验方益气活络汤联合甲钴胺注射液500ug皮下注射,较单纯应用甲钴胺注射液500ug皮下注射治疗糖尿病周围神经病,提高患者生活质量,延缓了病情进展,改善了患者体质。结论:从络病立论防治糖尿病周围神经病有良好的临床疗效,且安全性良好。“治络”的原则就是疏通络脉和透达络(毒)邪,为中医药治疗糖尿病周围神经病变提供了的新思路。
[Abstract]:Objective: to observe the clinical effect of prevention and treatment of diabetic peripheral neuropathy from collateral disease, and to compare the application of experience prescription Yiqi Huoluo decoction combined with 500ug injection subcutaneous injection. Compared with the treatment of diabetic peripheral neuropathy by subcutaneous injection of mecobalamin injection 500ug alone. Methods according to the history, symptoms, signs and diagnosis of diabetic peripheral neuropathy, 120 patients were randomly divided into treatment group (n = 60) and control group (n = 60). The symptoms and signs of diabetic peripheral neuropathy were not significantly different and comparable by statistical analysis (P 0.05). Because of the long history of the patients, both groups were given aspartic insulin 30 (produced by Nororod China Pharmaceutical Co., Ltd.) the blood glucose was controlled by subcutaneous injection of insulin in the morning and evening, and the dosage of hypoglycemic drugs was adjusted according to the level of blood sugar. The control group was subcutaneously injected with mecobalamin injection 500ug once a day. Treatment group on the basis of the control group oral Yiqi Huoluo decoction, 1 dose per day, water decoction 300 ml, divided into morning and evening, twice warm, the course of 4 weeks. There is a free decoction in the decoction room of our hospital. The clinical effect of the two groups was observed at the end of the course of treatment, and statistical analysis was carried out. Results according to the improvement of symptoms, signs and scores: the total effective rate of the treatment group was 86.67 and the total effective rate of the control group was 63.33.2 sensory nerve conduction velocity (SCV) and motor nerve conduction velocity (MCV) were compared before and after treatment. The treatment group was better than the control group (P 0.01.3) before and after treatment, and the two groups were compared with each other before and after treatment (P 0.05, P 0.05, P 0.05). The change of blood glucose in the treatment group was better than that in the control group before and after the treatment, the difference between the two groups was P0.05.The treatment group was superior to the control group in the application of P0.05.5.Experience Fang Yiqi Huoluo decoction combined with 500ug injection subcutaneous injection. The subcutaneous injection of mecobalamin injection 500ug was used to treat diabetic peripheral neuropathy, which improved the quality of life, delayed the progress of the disease and improved the physique of the patients. Conclusion: it is safe and effective to treat diabetic peripheral neuropathy from collateral disease. The principle of "treating collaterals" is to dredge the collaterals and toxin, which provides a new idea for the treatment of diabetic peripheral neuropathy by traditional Chinese medicine.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.2

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