细胞因子白细胞介素-6及胰岛素生长样因子-1与类风湿关节炎临床表现的关联性研究

发布时间：2018-06-05 15:42

本文选题：关节炎 + 类风湿　；参考：《中国骨质疏松杂志》2016年05期

【摘要】：目的研究白细胞介素-6(interleukin-6,IL-6)及胰岛素样生长因子-1(insulin-like growth factor-1,IGF-1)与类风湿关节炎(rheumatoid arthritis,RA)临床表现的关联性。方法采用酶联吸附免疫法(enzyme linked immunosorbent assay,ELISA)测定RA患者血清IL-6及IGF-1浓度,分析其于RA临床表现的关联性。结果1.骨质疏松组IGF-1水平明显低于无骨质疏松组(P0.05)。而男性组与女性组、RF阳性组与阴性组、ACCP阳性组与阴性组、无+轻度贫血与中度+重度贫血、白细胞减少与白细胞不减少、血小板升高与无血小板升高之间均无显著性差异(P0.05)。2.IGF-1与ACCP滴度、RF滴度、病程、ESR、年龄、CRP均无相关性(P0.05),与疼痛关节数及肿胀关节数呈负相关(P0.05)。3.男性RA患者IL-6水平明显比女性RA患者水平低(P0.05),ACCP阴性组明显比阳性组低(P0.05),骨质疏松组明显比无骨质疏松组低(P0.05)。而RF阳性组与阴性组、无+轻度贫血与中度+重度贫血、白细胞减少与白细胞不减少、血小板升高与无血小板升高之间均无显著性差异。(P0.05)。4.IL-6水平与ACCP滴度、疼痛关节数及肿胀关节数呈正相关(P0.05),与IGF-1水平呈负相关(P0.05),与RF滴度、病程、ESR、年龄、CRP均无相关性(P0.05)。结论IL-6及IGF-1与RA病情活动有关。女性患者Il-6高,易于发生骨质疏松
[Abstract]:Objective to study the relationship between interleukin-6 (IL-6) and insulin-like growth factor-1 (IGF-1) and rheumatoid arthritis (RA). Methods Serum IL-6 and IGF-1 levels in RA patients were measured by enzyme linked immunosorbent assaysa, and their correlation with clinical manifestations of RA was analyzed. Result 1. The level of IGF-1 in osteoporosis group was significantly lower than that in no osteoporosis group (P 0.05). However, there were no mild anemia and moderate severe anemia, leukopenia and leukopenia in male and female patients with RF positive and negative ACCP positive and negative. There was no significant difference between platelet elevation and no platelet elevation. 2. There was no significant difference between IGF-1 and ACCP titer and RF titer. There was no correlation between ACCP titer and age. There was a negative correlation between IGF-1 and pain joint number and swelling joint number. The level of IL-6 in male RA patients was significantly lower than that in female RA patients. The level of IL-6 in male RA negative group was significantly lower than that in positive group (P 0.05), and that in osteoporosis group was significantly lower than that in osteoporosis group (P 0.05). In RF positive group and negative group, there was no significant difference between mild anemia and moderate severe anemia, leukopenia and leukopenia, increase of platelet and no increase of platelet. 4. IL-6 level and ACCP titer were not significantly different between RF positive group and negative group. There was a positive correlation between the number of pain joints and the number of swollen joints (P0.05), a negative correlation with the level of IGF-1, and no correlation with RF titer, course of disease and age. Conclusion IL-6 and IGF-1 are related to RA disease activity. Female patients with high Il-6 are prone to osteoporosis
【作者单位】：安徽省淮北矿工总医院内分泌风湿科;
【分类号】：R593.22

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