山东地区456例汉族成年人血清维生素D状态研究

发布时间：2018-06-06 22:07

本文选题：山东地区 + 汉族人　；参考：《山东大学》2017年硕士论文

【摘要】：目的维生素D是一种具有多种重要生理功能的类固醇类激素,长期不足或缺乏维生素D则可能会导致骨量减少甚至骨质疏松症以及引发心血管系统疾病、自身免疫性疾病以及神经、精神类疾病等。本研究通过调查居住在山东地区汉族成年人血清25(OH)D的水平,获取本地区的成年人维生素D水平现状,并初步分析其影响因素。方法回顾性分析经山东大学齐鲁医院及山东省医学会骨质疏松学组血清维生素D水平网络调研平台收集的2015年4月-2016年8月的行血清25(OH)D检测的研究对象检测数据共849例,所有研究对象血清样本均为早晨抽取,排除患有糖尿病、甲状腺疾病者(74例),患有肾脏疾病者(41例),患有消化系统疾病者(31例),服用过维生素D和(或)钙补充剂者(42例),患有严重高脂血症及其他可能严重影响血清维生素D水平的疾病者(44例),非山东省居民(76例),非汉族居民(33例),年龄小于18岁样本(52例),最终共计456例纳入本项研究。将研究对象分别按照性别、年龄段、职业、居住地区(沿海地区与内陆地区、城镇与乡村)、采血时间(季节)进行细化分组研究,使用Stata 14.0对不同分组数据进行比较分析。所有研究对象对本研究均知情同意,所有样本均采用化学发光免疫法,所用检测盒均为Elecsys(?)Vitamin D total assay。结果1.456名研究对象血清25(OH)D平均值为14.25±8.23ng/m1,维生素D不足率为94.1%,维生素D缺乏率为78.5%;2.按研究对象年龄分组,不同年龄段研究对象的血清25(OH)D水平有明显差异,但其维生素D不足率与缺乏率无明显差异;3.按研究对象性别分组,不同性别研究对象的血清25(OH)D水平无明显差异,维生素D的不足率与缺乏率亦无明显差异;4.按研究对象职业分组,不同职业研究对象的血清25(OH)D水平有明显异,其中职业为农民的研究对象血清25(OH)D水平明显高于其他职业研究对象水平,但是不同职业研究对象的维生素D不足率与缺乏率无明显差异;5.按研究对象居住地区分组,居住在内陆地区和沿海地区研究对象的血清25(OH)D水平、维生素D不足率与缺乏率均无明显差异;居住在城镇和乡村的不同研究对象的血清25(OH)D水平、维生素D不足率与缺乏率均有明显差异,居住在乡村的研究对象的血清25(OH)D水平明显高于居住在城镇的研究对象,而其维生素D不足率与缺乏率均明显低于居住在城镇的研究对象;6.按研究对象采血时间分组,不同采血月份样本的血清25(OH)D水平、维生素D不足率与缺乏率之间有明显差异,采血时间在第三季度(7月、8月、9月)的样本血清25(OH)D水平明显高于其他季度的采血样本的水平,而其维生素D不足率与缺乏率明显低于其他季度采血样本的水平;7.多元线性回归与Logistic回归分析结果提示研究对象的性别、是否居住在沿海地区与血清25(OH)D水平无明显相关性,研究对象的年龄、职业、是否居住在城镇、样本的采血时间与血清25(OH)D水平有相关性,年龄、职业、是否居住在城镇、样本的采血时间是人群维生素D不足与缺乏的主要影响因素。结论1.山东省汉族成年人血清25(OH)D平均水平普遍较低,平均水平为14.25±8.23,人群中94.1%的个体维生素D处于不足状态,78.5%的个体维生素D处于缺乏状态;2.山东省汉族成年人维生素D营养状态与研究对象年龄、职业、是否居住在乡村、样本的采血时间有明显相关性;与研究对象的性别、是否居住在沿海地区无明显相关性。3.维生素D缺乏的危险因素为:①30岁及以下女性和70岁以上老年人②公务员、干部、学生和教师等职业③长期居住于城镇地区者④冬季
[Abstract]:Objective vitamin D is a steroid hormone with a variety of important physiological functions. Long term deficiency or lack of vitamin D may lead to osteopenia, osteoporosis, and cardiovascular diseases, autoimmune diseases, and neurologic, mental diseases, etc. This study was conducted to investigate the Han nationality inhabited in Shandong. The level of serum level of 25 (OH) D of the year was obtained, and the status of vitamin D in adults was obtained and its influencing factors were preliminarily analyzed. Methods the serum level of vitamin D in the osteoporosis group of Qilu Hospital of Shandong University and the network of serum vitamin D level in the osteoporosis group of the Shandong Medical Association were collected in April 2015 and August of -2016 year in April 2015. The subjects were tested for 849 cases. All the subjects were sampled in the morning, excluding diabetes, thyroid disease (74), patients with kidney disease (41 cases), patients with digestive system diseases (31 cases), vitamin D and (or) calcium supplements (42 cases), severe hyperlipidemia, and other serious influence on blood. Patients with vitamin D level (44 cases), non Shandong residents (76 cases), non Han residents (33 cases), age less than 18 years old (52 cases), and the final total of 456 cases were included in this study. The subjects were refined according to sex, age, occupation, residential area (along the sea area and inland area, town and country), blood collecting time (season). Group study, Stata 14 was used to compare the data of different groups. All the subjects were informed of the study. All the samples were treated with chemiluminescence immunoassay, and the detection boxes were Elecsys (?) Vitamin D total assay. results. The average value of serum 25 (OH) D was 14.25 + 8.23ng/m1, and vitamin D deficiency rate was 14.25. 94.1%, the vitamin D deficiency was 78.5%; 2. according to the age group, the level of serum 25 (OH) D of the subjects of different age groups had obvious difference, but there was no significant difference between the deficiency rate and the deficiency rate of vitamin D; 3. the level of serum 25 (OH) D of the subjects of different sex was no significant difference, and the deficiency rate of vitamin D The level of serum 25 (OH) D of the subjects of different occupations was significantly different, and the level of serum 25 (OH) D of the occupational group was significantly higher than that of other occupational research subjects, but there was no significant difference in the rate of vitamin D deficiency between the subjects of different career research subjects and the deficiency rate; 5 The levels of serum 25 (OH) D, vitamin D deficiency and deficiency rate of subjects living in inland and coastal areas were not significantly different from those in inland areas and coastal areas. The levels of serum 25 (OH) D and vitamin D infeet and deficiency rates of different research subjects living in towns and villages were significantly different, and the study of living in rural areas The level of serum 25 (OH) D of the subjects was significantly higher than that of the research subjects living in towns and towns, and their vitamin D deficiency rate and lack rate were significantly lower than those in urban areas. 6. according to the blood sampling time of the subjects, the levels of serum 25 (OH) D in different months of blood sampling, and the difference between the deficiency rate and the deficiency rate of vitamin D were significantly different. The levels of serum 25 (OH) D in the third quarter (July, August, September) were significantly higher than those of other quarterly blood sampling samples, while their vitamin D deficiency and deficiency rates were significantly lower than those of other quarterly blood sampling samples; 7. multivariate linear regression and Logistic regression analysis showed that the sex of the research subjects was living in the coastal areas. There was no significant correlation between the level of serum 25 (OH) D. The age, occupation, or living in the town, the blood sampling time of the sample was related to the level of serum 25 (OH) D, age, occupation, whether living in the town, and the sampling time was the main factor affecting the deficiency and deficiency of vitamin D in the population. Conclusion 1. serum of Han Adults in Shandong Province The average level of 25 (OH) D is generally low, the average level is 14.25 + 8.23, 94.1% of the individuals in the population are in the deficiency state of vitamin D, and 78.5% of the individual vitamin D is in a lack state; 2. the nutritional status of vitamin D in the Han Adults in Shandong Province has a significant correlation with the age of the subjects, the occupation, whether living in the countryside, and the sampling time. The risk factors for the gender, whether living in the coastal areas without significant correlation of.3. vitamin D deficiency are: (1) 30 years old and below women and older people over 70 years of age (2) civil servants, cadres, students and teachers (3) for a long time in urban areas
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R580

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