骨胶原属性与骨强度关系研究进展

发布时间：2018-06-10 00:54

本文选题：胶原 + 骨强度　；参考：《中国骨质疏松杂志》2017年09期

【摘要】：骨组织作为一种复杂的生物复合材料,胶原是其重要的有机组成成分,为骨组织提供韧性以维持骨组织良好的生物力学性能。大量的研究表明,骨质疏松症等能导致骨强度降低的疾病发生时,骨组织胶原属性会发生显著改变。在决定骨强度方面,骨胶原属性已经成为独立于骨密度之外的决定性参数。研究骨组织的胶原属性对骨强度的影响,能更好的理解骨质疏松症等疾病的发病机制,并为评估人体骨强度提供重要参考信息。根据文献回顾,骨胶原分子结构、胶原纤维排布走向、胶原分子间的交联等都会对骨强度产生显著影响,同时笔者重点总结了骨质疏松症和糖尿病两种导致骨强度降低的疾病发生时,骨胶原属性会发生如下改变:胶原排布走向改变、基团修饰改变和糖基化改变增加等。
[Abstract]:As a complex biological composite, collagen is an important organic component of bone tissue, which provides toughness for bone tissue to maintain good biomechanical properties of bone tissue. A large number of studies have shown that bone tissue collagen properties change significantly when diseases such as osteoporosis can lead to lower bone strength. In determining bone strength, collagen properties have become a decisive parameter independent of bone mineral density (BMD). Studying the effect of collagen properties on bone strength can better understand the pathogenesis of osteoporosis and provide important reference information for evaluating human bone strength. According to literature review, the molecular structure of bone collagen, the arrangement of collagen fibers, and the cross-linking of collagen molecules all have significant effects on bone strength. At the same time, the author summarized that when osteoporosis and diabetes caused the decrease of bone strength, the changes of collagen properties were as follows: the change of collagen arrangement, the change of group modification and the increase of glycosylation, etc.
【作者单位】：解放军第四六三医院骨科;
【基金】：辽宁省自然科学基金面上项目(201700773)
【分类号】：R580

【相似文献】