动态血糖序列的精细复合多尺度熵分析

发布时间：2018-06-11 22:36

本文选题：h动态血糖 + 血糖波动　；参考：《生物医学工程学杂志》2017年01期

【摘要】：血糖波动复杂性的研究有助于理解血糖调节系统的内在规律。本文以Ⅱ型糖尿病患者(93人)72 h动态血糖序列为分析对象,使用多尺度熵分析技术研究动态血糖序列结构的复杂性。针对72 h动态血糖序列较短的问题,采用了最新改进的精细复合多尺度熵(RCMSE)分析技术,分别观察了基于平均血糖波动幅度(MAGE)和糖化血红蛋白(Hb A1c)进行分组的糖尿病患者的血糖波动复杂性。研究发现,MAGE值大的组其复杂度低,熵值在尺度1~6(5~30 min)之间的差异具有统计学意义,Hb A1c值高的组其复杂度也较低,但是分组之间的熵值差异没有统计学意义。本文研究结果表明,血糖调控不好(无论从MAGE值还是从Hb A1c值来看),将会带来血糖序列动态结构复杂度的损失。本文所提的RCMSE分析技术可为血糖序列波动分析提供一个新的视角,血糖序列复杂度有可能成为血糖波动分析的一个新的生物学指标。
[Abstract]:The study of the complexity of blood glucose fluctuation helps to understand the inherent laws of the blood glucose regulation system. In this paper, the dynamic blood glucose sequences of 93 patients with type 2 diabetes mellitus were analyzed. The complexity of the dynamic blood glucose sequences was studied by multi-scale entropy analysis. In order to solve the problem of short dynamic blood glucose sequence in 72 hours, the newly improved multiple scale Entropy (RCMSE) analysis technique was adopted. The complexity of blood glucose fluctuation in diabetic patients divided into groups based on mean blood glucose fluctuation amplitude (MAGEG) and glycosylated hemoglobin (HbA1c) was observed. It was found that the complexity of the group with large age value was low, and the difference of entropy value between the two groups was statistically significant. The complexity of the group with high HbA1c value was lower, but there was no significant difference in entropy value between the groups. The results of this study show that poor blood glucose regulation (whether viewed from mage or HbA1c) will result in the loss of dynamic structural complexity of blood glucose sequences. The RCMSE technique proposed in this paper can provide a new perspective for the analysis of the fluctuation of blood glucose sequence, and the complexity of the blood glucose sequence may become a new biological index for the analysis of the fluctuation of blood sugar.
【作者单位】：北京理工大学生命学院;解放军总医院内分泌科;解放军总医院医学工程保障中心;
【基金】：国家自然科学基金面上资助项目(61471398) 解放军总医院临床扶持基金资助项目(2014FC-TSYS-2007)
【分类号】：R587.1

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