乌鲁木齐二道桥片区维吾尔族男性胰岛功能与体脂及相关因素分析

发布时间：2018-06-11 23:04

本文选题：胰岛功能 + 体脂分布　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨维吾尔族男性人群中胰岛功能与体脂分布及其他影响因素的相关性。方法:使用随机整群抽样的方法在新疆维吾尔自治区乌鲁木齐市二道桥片区纳入597名男性,采集人体学参数,予以问卷调查、口服葡萄糖耐量试验并行实验室检查,采用生物电阻抗法测量体脂分布。结果:受试者中糖代谢异常与正常组的体质指数(BMI)、腰臀比(WHR)、内脏脂肪面积均有统计学差异(P0.05)。按体脂分布各组分分别进行分组,各组间胰岛素抵抗指数均有统计学差异(P0.05)。线性相关显示,内脏脂肪面积、体脂百分比、BMI、WHR、甘油三酯(TG)、血糖、血压与HOMA-IR呈正相关(P0.05),低密度脂蛋白、睾酮、性激素结合球蛋白、25羟维生素D与HOMA-IR呈负相关(P0.05),血糖、甘油三酯与HOMA-?呈负相关(P0.05)。逐步回归分析显示,空腹血糖(FPG)、内脏脂肪面积、糖代谢分类为lnHOMA-?的主要影响因素,FPG、内脏脂肪面积、腰臀比、腰围、性激素结合球蛋白、BMI、睾酮为lnHOMA-IR的主要影响因素。结论:不论全身性还是中心性肥胖均有胰岛素抵抗的风险,血糖、内脏脂肪面积为胰岛素抵抗、胰岛β细胞功能的主要影响因素,性激素结合球蛋白及睾酮在男性中或许可作为胰岛素抵抗的预测因子。
[Abstract]:Objective: to investigate the relationship between islet function, body fat distribution and other influencing factors in Uygur male population. Methods: 597 men were enrolled in Erdaoqiao district of Urumqi, Xinjiang Uygur Autonomous region by random cluster sampling method. Anthropometric parameters were collected, questionnaire was conducted and oral glucose tolerance test was performed in laboratory. The distribution of body fat was measured by biological impedance method. Results: body mass index (BMI), waist to hip ratio (WHR) and visceral fat area of the subjects with abnormal glucose metabolism were significantly different from those of the normal group (P 0.05). The insulin resistance index of each group was significantly different according to body fat distribution (P 0.05). Linear correlation showed that the area of visceral fat, percentage of body fat, triglyceride TGG, blood sugar, blood pressure and HOMA-IR were positively correlated with HOMA-IR, low density lipoprotein, testosterone, androgen binding globulin 25 hydroxyvitamin D were negatively correlated with HOMA-IR, blood glucose, triglyceride and HOMA-IR were negatively correlated. There was a negative correlation (P0.05). Stepwise regression analysis showed that fasting blood glucose FPGN, visceral fat area, glucose metabolism classified as lnHOMA-? The main influencing factors were FPG, visceral fat area, waist-to-hip ratio, waist circumference, sex hormone binding globulin BMIand testosterone as the main influencing factors of lnHOMA-IR. Conclusion: both systemic and central obesity have the risk of insulin resistance, blood glucose and visceral fat area are the main factors influencing the function of islet 尾 cells. Sex hormone binding globulin and testosterone may be used as predictors of insulin resistance in men.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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