实时剪切波弹性成像评估强的松治疗桥本甲状腺炎

发布时间：2018-06-14 00:04

本文选题：桥本甲状腺炎 + 实时剪切波弹性成像　；参考：《实用医学杂志》2017年21期

【摘要】：目的探讨实时剪切波弹性成像(SWE)技术对桥本甲状腺炎(HT)患者服用强的松后疗效评价的临床应用价值。方法应用SWE技术测量45例临床确诊为HT所致亚临床甲减状态的患者应用强的松治疗前和治疗1个月后的甲状腺组织的各项杨氏模量值,并用配对t检验分析比较其治疗前后的差异。结果应用强的松治疗前和治疗1个月后对比,患者甲状腺组织杨氏模量值及血清促甲状腺激素(TSH)浓度、甲状腺过氧化物酶抗体(TPOAb)及抗甲状腺球蛋白抗体(TGAb)差异均有统计学意义(P0.05),治疗后患者的各项模量值均有不同程度的降低,并且患者的血清TSH均恢复正常。结论通过SWE定量测量甲状腺组织的杨氏模量值可获得客观的组织硬度信息,为评价强的松对HT患者的治疗效果及病情进展情况提供更有意义的参考依据,具有重要的影像学及临床研究价值。
[Abstract]:Objective to evaluate the clinical value of real-time shear wave elastography (SWE) in evaluating the efficacy of prednisone in patients with Hashimoto's thyroiditis. Methods SWE technique was used to measure the Young's modulus of thyroid tissue in 45 patients with subclinical hypothyroidism caused by HT before and one month after prednisone treatment. The difference before and after treatment was analyzed by paired t test. Results the levels of Young's modulus in thyroid tissue and serum thyroid stimulating hormone TSHs were compared between prednisone and one month after treatment. There were significant differences in thyroid peroxidase antibody (TPO) and anti-thyroglobulin antibody (TGAb) between the two groups (P 0.05). After treatment, the moduli of the patients were decreased to varying degrees, and the serum TSH of the patients returned to normal. Conclusion the objective information of tissue hardness can be obtained by quantitative measurement of Young's modulus of thyroid tissue by SWE, which provides a more meaningful reference basis for evaluating the therapeutic effect of prednisone on patients with HT and the progress of the disease. It has important imaging and clinical value.
【作者单位】：滨州医学院附属医院超声医学科;滨州医学院附属医院内分泌科;
【基金】：山东省卫生和计划生育委员会科技计划项目(编号:2014-38)
【分类号】：R445.1;R581.4

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