硬皮病骨密度、血清维生素D水平与皮肤纤维化的关系

发布时间：2018-06-14 10:23

本文选题：硬皮病 + 骨密度　；参考：《中国骨质疏松杂志》2017年04期

【摘要】：目的通过测定初诊女性硬皮病患者的骨密度,检测其血清25羟维生素D水平,评估皮肤纤维化程度,探究3者之间的相关性。方法纳入本院2013年6月至2016年6月门诊或住院初诊女性硬皮病患者(n=60)和健康体检者(n=20),采用双能X线吸收法测定腰椎、双髋骨密度,收集实验室25(OH)D_3的结果,计算皮肤病变的mRSS评分,然后进行组间及组内的统计分析。结果初诊女性硬皮病患者双髋、腰椎的骨密度明显低于健康体检者(P0.05),其中弥漫硬皮型患者上述部位骨密度均显著低于局限硬皮型患者(P0.05)。硬皮病患者25(OH)D_3水平也显著低于健康体检者(P0.05),其中弥漫硬皮型患者25(OH)D_3水平低于局限硬皮型患者(P0.05)且与皮肤病变的mRSS评分成负相关(r=-0.946,P0.05)。结论初诊女性硬皮病患者在未应用激素与免疫抑制剂治疗前已经存在显著骨矿含量下降,维生素D缺乏,这与患者皮肤受累硬化程度相关。皮肤纤维化程度的升高,阻碍了皮肤维生素D的合成,可能是导致初诊女患者骨矿含量下降,骨质疏松的一个重要原因。
[Abstract]:Objective to detect the bone mineral density of patients with early diagnosis of scleroderma, to detect the level of serum 25 hydroxyvitamin D, to evaluate the degree of skin fibrosis and to explore the correlation between the 3. Methods the method was included in the hospital from June 2013 to June 2016 for the first diagnosis of female scleroderma (n=60) and health examiners (n=20), and the dual energy X-ray absorption method was used to determine the degree. The results of 25 (OH) D_3 of the laboratory were collected from the lumbar vertebra and the double hip bone density. The mRSS score of the skin lesions was calculated, and then the statistical analysis between the groups and the groups was carried out. Results the bone mineral density of the first diagnosed female scleroderma was significantly lower than that of the healthy persons (P0.05), and the bone mineral density in the above parts of the diffuse hard skin patients was significantly lower than that of the limited hardened patients. Patients with skin type (P0.05). 25 (OH) D_3 levels in scleroderma were also significantly lower than those in physical examination (P0.05), of which 25 (OH) D_3 levels in diffuse hard skin patients were lower than those of localized scleroderma (P0.05) and negatively correlated with mRSS scores of skin lesions (r=-0.946, P0.05). There has been a significant decrease in bone mineral content and vitamin D deficiency, which is related to the degree of skin involvement and sclerosis in patients. The increase of the degree of skin fibrosis hinders the synthesis of vitamin D in the skin, which may be an important cause of the decrease in bone mineral content and osteoporosis in first diagnosed women.
【作者单位】：中国医科大学附属盛京医院风湿免疫科;
【基金】：辽宁省科学计划项目(2014225017)
【分类号】：R593.25

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