英夫利昔致药物性狼疮31例文献分析

发布时间：2018-06-14 13:38

本文选题：英夫利昔 + 药物性狼疮　；参考：《中国药房》2017年14期

【摘要】：目的:分析英夫利昔致药物性狼疮(DIL)的发生规律及特点,为安全用药提供参考。方法:以"英夫利昔""狼疮"等为检索词,检索2002年1月-2016年6月中国学术期刊全文数据库(CJFD)、维普中文科技期刊数据库(VIP)及Pub Med等数据库,对英夫利昔致DIL的相关文献进行分析。结果:共检索得到有效文献30篇,共计31例DIL患者。其中,男性8例(25.81%),女性23例(74.19%),年龄50岁的中老年患者17例(54.84%);发生在5~24周有20例(64.51%);单独使用英夫利昔方案者16例(51.61%);主要临床表现为皮疹或光敏性肠炎(15例)、关节痛(16例,多发性关节炎及滑膜炎)和发热(12例),有5例患者同时出现上述3种症状;实验室检查主要表现为抗核抗体、双链DNA抗体及抗组蛋白抗体阳性;除1例患者继续用药外,其余30例DIL患者给予停药或甾体激素治疗,其中26例患者于停药或治疗后6个月之内症状消失,1例患者病情恶化。结论:英夫利昔致DIL的发生涉及患者年龄、性别、疾病种类、家庭史等多种因素,临床应加强用药监测,减少不良反应的发生。
[Abstract]:Objective: to analyze the occurrence and characteristics of infliximab-induced drug-induced lupus erythematosus (Dil) in order to provide reference for safe drug use. Methods: using "inflixion" and "lupus" as the key words, we searched the full text database of Chinese academic journals from January 2002 to June 2016, including CJFDG, VIPs, Pub Med and so on. To analyze the related literature of inflexion induced DIL. Results: a total of 30 effective literatures were retrieved, including 31 patients with DIL. Among them, 8 males (25. 81%), 23 females (74. 19%), 17 middle-aged and aged 50 years old patients (54.84); 20 cases (64.51m) who occurred in 524 weeks; 16 cases (51.61) were treated with infliximab alone; the main clinical manifestations were rash or Guang Min enteritis (15 cases) and arthralgia (16 cases). There were 12 cases of polyarthritis and synovitis, and 5 cases of fever had the above three symptoms simultaneously. Laboratory examination mainly showed that the antinuclear antibody, double strand DNA antibody and anti histone antibody were positive. The other 30 patients with DIL were given withdrawal or steroid therapy, of which 26 patients had their symptoms disappeared within 6 months after withdrawal or treatment. Conclusion: the incidence of DIL caused by infliximab is related to age, sex, disease type, family history and so on. The clinical monitoring of DIL should be strengthened to reduce the incidence of adverse reactions.
【作者单位】：蚌埠市第三人民医院药学部;
【分类号】：R593.24

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