血清脂氧素A4水平与2型糖尿病周围神经病变的相关性研究

发布时间：2018-06-16 13:49

本文选题：脂氧素A + 糖尿病　；参考：《中国糖尿病杂志》2017年02期

【摘要】：目的探讨血清脂氧素A4(LXA4)与糖尿病周围神经病变(DPN)的相关性。方法选择新诊断的单纯T2DM患者41例(T2DM组),DPN患者42例(DPN组),另选体检者42名(NGT组)。采用ELISA测定血清LXA4水平。结果与NGT组比较,T2DM组和DPN组血清LXA4水平降低[(540.23±55.87)vs(511.49±51.23)vs(476.53±47.23)pg/ml,P0.05或P0.01];相关分析显示,血清LXA4水平与FPG、HbA_1 c、TNF-α、半胱氨酸天冬氨酸酶3(Caspase-3)、病程呈负相关(r=-0.501、0.541、-0.627、-0.638,-0.591,P0.05或P0.01);与血红素加氧酶-1(HO-1)、超氧化物歧化酶(SOD)、正中神经运动神经传导速度(MMCV)、腓总神经运动神经传导速度(PMCV)、正中神经感觉神经传导速度(MSCV)、腓总神经感觉神经传导速度(PSCV)呈正相关(r=0.578、0.510、0.628、0.611、0.549、0.625,P0.05或P0.01);Logistic回归分析显示,LXA4、TNF-α是DPN的独立影响因素。结论DPN患者血清LXA4水平下降,在DPN的发生中发挥重要作用。
[Abstract]:Objective to investigate the correlation between serum lipoxygenin A 4 and diabetic peripheral neuropathy (DPN). Methods 41 newly diagnosed patients with T2DM and 42 patients with DPN and 42 patients with NGT were selected. Serum LXA 4 levels were measured by Elisa. Results compared with NGT group, serum LXA4 level in T2DM group and DPN group was decreased [540.23 卤51.23)vs(476.53 卤47.23 g / ml P 0.05 or P0.01]. The level of serum LXA4 is negatively correlated with the levels of TNF- 伪, Caspase-3 and Caspase-3 of FPG HbA1, and is negatively correlated with the course of disease (P 0.05 or P0.01), and with heme oxygenase-1 (HO-1), superoxide dismutase (SOD), median nerve motor velocity (MMCVV), common peroneal nerve conduction velocity (PMCV), positive peroneal nerve motor nerve conduction velocity (PMCVV), and heme oxygenase-1 (HO-1), superoxide dismutase (SOD), median nerve motor nerve conduction velocity (MMCVV), peroneal nerve motor nerve conduction velocity (PMCVV), positive peroneal nerve motor nerve conduction velocity (MMCVV), peroneal nerve motor nerve conduction velocity. The median nerve sensory nerve conduction velocity (MSCV) and the common peroneal nerve sensory nerve conduction velocity (PSCV) were positively correlated with RV 0.578U 0.510 0. 628 C 0. 611 0. 549 0. 625 P 0.05 or P 0. 01% logistic regression analysis showed that LXA4 + TNF- 伪 was an independent influencing factor of DPN. Conclusion the decrease of serum LXA 4 level in DPN patients may play an important role in the pathogenesis of DPN.
【作者单位】：三峡大学仁和医院内分泌科;
【分类号】：R587.2

【参考文献】