新诊断型糖尿病患者血脂比值特点及短期胰岛素强化治疗对其影响

发布时间：2018-06-20 11:46

本文选题：型糖尿病 + 新诊断　；参考：《实用医学杂志》2017年11期

【摘要】：目的:观察新诊断2型糖尿病(T2DM)患者血脂比值的特点,并探讨短期胰岛素强化治疗对其影响。方法:入组90例新诊断T2DM患者及58例血糖正常对照者,测定两组的身高、体质量、血糖及血脂谱,计算BMI、TC/HDL-C、TG/HDL-C、log(TG/HDL-C)、LDL-C/HDL-C以及HOMA-B和HOMA-IR。T2DM组予胰岛素泵持续皮下输注胰岛素,血糖达标后维持10~14 d,复查上述指标。结果:与对照组相比,新诊断T2DM组血脂异常主要表现为高TG血症及低HDL-C血症比例较高(P0.05),与HDL-C相关的各血脂比值明显升高(P0.01)。短期胰岛素强化治疗后患者的各项血脂比值均较治疗前显著下降,且变化值均与HOMA-IR的变化值呈显著正相关(P0.05)。结论:短期胰岛素强化治疗可显著降低新诊断T2DM患者中升高的HDL-C相关血脂比值,并与改善胰岛素抵抗密切相关。
[Abstract]:Objective: to observe the characteristics of blood lipid ratio in newly diagnosed type 2 diabetes mellitus (T2DM) patients and to explore the effect of short term intensive insulin therapy. Methods: 90 newly diagnosed T2DM patients and 58 normal controls were enrolled in this study. Height, body weight, blood glucose and blood lipids of the two groups were measured, and insulin was continuously infused subcutaneously into the BMITC / HDL-C / TG- / TG- / HDL-Clog / TG-C / HDL-C / T2DM, HOMA-B and HOMA-IR.T2DM groups. The blood glucose was maintained for 10 ~ 14 days and the above indexes were reexamined. Results: compared with the control group, hypertriglyceridemia and low HDL-C were the main manifestations of hypertriglyceridemia and low HDL-C in the newly diagnosed T2DM group (P 0.05). The ratio of serum lipids related to HDL-C was significantly higher in the newly diagnosed T2DM group than that in the control group (P 0.01). After short-term intensive insulin therapy, the ratio of serum lipids decreased significantly, and the changes were positively correlated with the changes of HOMA-IR. Conclusion: Short-term intensive insulin therapy can significantly reduce the ratio of HDL-C related lipids in newly diagnosed T2DM patients, and is closely related to the improvement of insulin resistance.
【作者单位】：中山大学孙逸仙纪念医院临床营养科;中山大学孙逸仙纪念医院儿科;中山大学孙逸仙纪念医院内分泌科;
【基金】：国家自然科学基金(编号:81270915) 广东省自然科学基金(编号:2015A030313042)
【分类号】：R587.1

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