类风湿关节炎达标治疗相关影响因素的临床研究

发布时间：2018-06-21 16:33

  本文选题：关节炎 + 类风湿　； 参考：《中华疾病控制杂志》2016年06期

【摘要】：目的调查类风湿关节炎患者(rheumatoid arthritis,RA)达标治疗情况,分析其影响因素,进一步提高RA达标治疗率。方法选择300例RA患者,详细记录所有患者临床资料,并根据28关节疾病活动性(disease activity score in 28 joints,DAS28)评分分为达标组和未达标组。结果 RA患者中,达标率为36.7%;达标组和未达标组比较:达标组比未达标组患者平均年龄轻、文化程度高、关节肿胀数/关节压痛数少、疼痛程度评分/患者总体评估/医师总体评估(physician global assessment,PGA)低;达标组持续使用致病情缓解抗风湿病药(disease-modifying anti-rheumatic drugs,DMARDs)单药或联合治疗时间≥3个月所占比例高于未达标组;达标患者类风湿因子、红细胞沉降率、C反应蛋白、关节功能分级、生活质量得分低于未达标患者;Logistic回归分析显示:关节功能分级、C反应蛋白、PGA是RA达标治疗独立影响因素。结论 RA患者达标治疗率仍较低,DMARDs正规治疗对达标治疗具有重要作用,关节功能、C反应蛋白、PGA为RA达标治疗独立影响因素。
[Abstract]:Objective to investigate the treatment of rheumatoid arthritis (RA) in rheumatoid arthritis (RA) and analyze its influencing factors. Methods three hundred patients with RA were selected and all the clinical data were recorded in detail. According to the score of 28 joint disease activity score in 28 join as 28, the patients were divided into two groups: the control group and the non-standard group. Results in RA patients, the rate of reaching the standard was 36.7%, the average age of the patients in the standard group was lower than that in the non-standard group, the education level was higher, the number of joint swelling / joint tenderness was less than that in the non-standard group. The scores of pain degree / total assessment of patients / physicians' overall assessment of PGAs were lower, the proportion of patients with persistent use of disease mitigation drug DMARDs1 or DMARDs鈮，

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