甲状腺功能减退患者血清FGF-21的表达水平及其生化指标相关性分析

发布时间：2018-06-21 22:32

本文选题：甲状腺功能减退 + FGF-　；参考：《中国地方病防治杂志》2016年11期

【摘要】：目的探讨甲状腺功能减退患者血清中FGF-2的表达水平及其生化指标相关性分析。方法选择甲亢患者62例做为甲亢组,甲减患者52例做为甲减组,同期体检健康者54例做为对照组;分别采用酶联免疫吸附法(ELISA)检测FGF-21,化学发光仪检测TSH、FT_3、FT_4,生化分析仪检测TC、TG、LDL、HDL等指标水平。结果甲减组血清FGF-21、TSH、TC、TG、LDL高于对照组(P0.05),FT_3、FT_4、HDL低于对照组(P0.05);甲亢组血清FGF-21、TSH、TC、TG、LDL均低于对照组(P0.05),FT_3、FT_4、HDL高于对照组(P0.05)。甲减患者FGF-21水平与年龄、性别、TSH、TC、LDL呈正相关。结论血清FGF-21在甲减患者中表达水平升高,同时与TSH、TC、TG、LDL指标有相关性,可能是导致甲状腺功能异常的危险因素并参与疾病的发生发展;甲减患者随TC、TG、LDL升高,也可能是导致血脂异常的主要原因之一。
[Abstract]:Objective to investigate the expression of FGF-2 in serum of patients with hypothyroidism and its correlation with biochemical indexes. Methods 62 patients with hyperthyroidism were selected as hyperthyroidism group, 52 patients with hypothyroidism as hypothyroidism group and 54 healthy persons as control group. Enzyme linked immunosorbent assay (Elisa) was used to detect FGF-21, chemiluminescence (CL) to detect TSHT / T _ T _ 3 / FT _ 4, and biochemical analyzer to detect the level of TGG / LDL / HDL. Results in hypothyroidism group, the serum FGF-21TSHTC- TGC TGN LDL was significantly higher than that in the control group (P0.05), and the serum FGF-21 TSHC TCC TGO LDL level in hyperthyroidism group was lower than that in the control group (P0.05), and the level of FT3 FT4HDL in hyperthyroidism group was significantly higher than that in control group (P0.05), and that in hyperthyroidism group was significantly lower than that in control group (P0.05). The level of FGF-21 in hypothyroidism patients was positively correlated with age and sex. Conclusion the expression of serum FGF-21 in hypothyroidism patients is higher than that in patients with hypothyroidism, and it may be a risk factor for thyroid dysfunction and participate in the development of the disease. It may also be one of the main causes of dyslipidemia.
【作者单位】：吉林医药学院检验学院;北华大学附属医院;
【基金】：国家自然科学基金(81273421) 大学生创新创业项目
【分类号】：R581.2;R446.1

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