维生素B12、叶酸联合沙格列汀对2型糖尿病患者血清胱抑素C、尿酸及氧化应激水平的影响

发布时间：2018-06-25 15:21

本文选题：型糖尿病 + 沙格列汀　；参考：《中国老年学杂志》2016年19期

【摘要】：目的探究维生素B12、叶酸联合沙格列汀对2型糖尿病(T2DM)患者血清胱抑素C(Cys C)、尿酸(UA)及氧化应激水平的影响。方法T2DM患者96例,随机分成2组,每组48例。对照组给予沙格列汀治疗,联合组在对照组的基础上给予维生素B12、叶酸治疗,共4 w。检测治疗前后血液生化指标、氧化应激指标及肾功能指标。结果与对照组比较,联合组观察指标均得到改善,表现为血清Cys C水平较低(P0.05);超氧化物歧化酶(SOD)、一氧化氮(NO)较高(P0.05);丙二醛(MDA)、内皮素(ET)-1较低(P0.05);尿素氮(BUN)、肌酐(Scr)、UA及24 h尿蛋白排泄率(24 h UPE)较低(P0.05)。结论维生素B12、叶酸联合沙格列汀能有效降低T2DM患者血清Cys C水平,改善氧化应激状态及肾功能,调节糖代谢,值得临床推广。
[Abstract]:Objective to investigate the effects of vitamin B12, folic acid and salgletine on serum cystatin C (Cys C), uric acid (UA) and oxidative stress levels in patients with type 2 diabetes mellitus (T2DM). Methods 96 patients with type 2 DM were randomly divided into 2 groups, 48 cases in each group. The control group was treated with salglutin and the combined group with vitamin B12 and folic acid for 4 ws. Blood biochemical index, oxidative stress index and renal function index were measured before and after treatment. Results compared with the control group, the observation indexes of the combined group were improved. The serum levels of Cys C were lower (P0.05), superoxide dismutase (SOD) and nitric oxide (no) were higher (P0.05), malondialdehyde (MDA) and endothelin (et) -1 were lower (P0.05), urea nitrogen (bun), creatinine (SCR) and urinary protein excretion rate (24 h UPE) were lower (P0.05). Conclusion Vitamin B12, folic acid combined with salgletine can effectively reduce serum Cys C level, improve oxidative stress state and renal function and regulate glucose metabolism in patients with T2DM.
【作者单位】：胜利石油管理局胜利医院内分泌科;
【分类号】：R587.1

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