骨质疏松症患者骨密度与血清25羟维生素D的相关性研究

发布时间：2018-06-28 08:24

本文选题：血清羟维生素D + 骨密度　；参考：《中国骨质疏松杂志》2017年07期

【摘要】：目的分析骨质疏松症患者骨密度与血清25羟维生素D的相关性。方法记录397例50~97岁患者的年龄,检测腰椎1~4、左侧股骨颈、左侧股骨上端的骨密度(bone mineral density,BMD),检测骨质疏松4项[甲状旁腺素(parathyroid hormone,PTH)、总I型胶原氨基端前肽(procollagen type 1 amino-terminal propeptide,P1NP)、β胶原降解产物(beta collagen degradation products,β-CTX)、N端骨钙素(N end of osteocalcin,N-MID)]及血清25羟维生素D[25-(OH)D]的水平,根据BMD水平将受试者分为骨量正常组(n=118)、骨量低下组(n=153)和骨质疏松组(n=126)。结果 (1)骨量低下组及骨质疏松组的BMD均明显低于正常骨量组(P0.01),骨质疏松组又明显低于骨量低下组(P0.01);(2)骨质疏松组25-(OH)D、PTH、P1NP、β-Crosslaps及N-CTX均明显低于正常骨量组(P0.01);(3)25-(OH)D与腰椎1~4、左侧股骨颈、左侧股骨上端的BMD、PTH、P1NP、β-CTX无相关性(P0.05),25-(OH)D与N-MID的相关系数为0.193(P0.01)。不同骨密度组间的25-(OH)D差异无统计学意义(P0.05)。结论老年人群普遍存在维生素D(vitamin D,VD)水平不足的现象,而骨质疏松症患者更为突出,其中VD严重缺乏和缺乏所占比例较大,为骨质疏松症的防治提供一定的数据参考,应注意加强宣教及防治。尚未发现25-(OH)D与骨密度之间存在着直接相关关系。
[Abstract]:Objective to analyze the correlation between bone mineral density (BMD) and 25 hydroxyvitamin D in patients with osteoporosis. Methods the age of 397 patients aged 50 to 97 years was recorded, and the lumbar vertebrae 1, 4, and the left femoral neck were detected. The bone mineral density (bone mineral) of the left femur was measured to detect the levels of 4 items of osteoporosis [parathyroid hormone, total type I collagen prepeptide (procollagen type 1 amino-terminal propeptide P1NP, 尾 -CTX] N-terminal osteocalcin N-MID and serum 25 hydroxyvitamin D (25 (OH) D). According to the level of BMD, the subjects were divided into normal bone mass group (nm118), low bone mass group (nang153) and osteoporosis group (nnm126). Results (1) the BMD of low bone mass group and osteoporosis group were significantly lower than that of normal bone mass group (P0.01), and that of osteoporosis group was significantly lower than that of low bone mass group (P0.01); (2), and that of 25- (OH) D); (P1NPP, 尾 -Crosslaps and N-CTX of osteoporosis group were significantly lower than that of normal bone mass group (P0.01); (3) 25- (OH) D and lumbar vertebrae (1H) 4, and left femoral neck significantly lower than that of normal bone mass group (P0.01); (3) 25- (OH) D and lumbar vertebrae 4, left femoral neck. There was no correlation between P1NPand 尾 -CTX and N-MID (P0.05). The correlation coefficient between BMD-PTHX and N-MID was 0.193 (P0.01). There was no significant difference in 25-(OH) D between different BMD groups (P0.05). Conclusion the phenomenon of vitamin D (vitamin D D) deficiency is common in the elderly, especially in the patients with osteoporosis, in which the proportion of VD is serious deficiency and deficiency, which provides a certain data reference for the prevention and treatment of Osteoporosis. Attention should be paid to strengthening propaganda and prevention. There is no direct correlation between 25-(OH) D and bone mineral density.
【作者单位】：广州总医院;广州中医药大学;
【基金】：中央军委后勤保障部卫生局保健专项课题(16BJZ57,13BJZ13)
【分类号】：R580

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