养阴消瘿方联合西药治疗Graves病的临床疗效分析

发布时间：2018-06-28 12:58

本文选题：Graves病 + 养阴消瘿方　；参考：《重庆医学》2017年29期

【摘要】：目的分析养阴消瘿方联合西药治疗Graves病患者的临床疗效及其作用机制。方法选择2012年1月至2014年12月于该院内分泌门诊初次就诊的Graves病患者50例,采用随机数字表法将患者分为观察组和对照组,各25例。另选取同期行健康查体者25例作为健康对照组。对照组给予甲巯咪唑、普萘洛尔等西药治疗,观察组在西药基础上给予养阴消瘿方治疗,均治疗2个月。观察3组治疗前后血清游离三碘甲状腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)水平,辅助性T淋巴细胞(Th)1、Th2、Th17占CD4+细胞的百分比及其相对应的细胞因子水平。结果观察组与对照组患者治疗后FT3、FT4、TGAb及TPOAb水平较治疗前均明显下降,TSH水平明显上升(P0.05),两组患者Th1、Th2及Th17细胞百分比均较治疗前明显降低(P0.05)。观察组与对照组患者治疗后干扰素-γ(IFN-γ)、白细胞介素(IL)-4水平、IFN-γ/IL-4比值及IL-12、IL-5水平、IL-12/IL-5比值较治疗前均明显下降(P0.05)。观察组与对照组患者治疗后IL-17A、IL-17F、IL-23水平较治疗前明显降低(P0.05)。并且治疗后观察组上述各项指标均优于对照组(P0.05)。结论养阴消瘿方联合西药治疗Graves病的临床疗效确切,可明显改善患者的甲状腺功能。
[Abstract]:Objective to analyze the clinical effect and mechanism of Yangyin Xiaoying prescription combined with western medicine in the treatment of Graves disease. Methods from January 2012 to December 2014, 50 patients with Graves' disease were randomly divided into two groups: the observation group and the control group. Another 25 cases were selected as healthy control group. The control group was treated with methimazole and propranolol, while the observation group was treated with Yangyin Xiaoying recipe for 2 months. Serum free triiodothyronine (FT3), serum free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TGAb), thyroid peroxidase antibody (TPOAb) were observed before and after treatment. The percentage of T helper T lymphocytes (Th) and Th2T17 in CD4 cells and their corresponding cytokine levels. Results the levels of TGAb and TPOAb in the observation group and control group were significantly lower than those before treatment (P0.05), and the percentage of Th1Th2 and Th17 cells in the two groups were significantly lower than that before treatment (P0.05). The levels of IFN- 纬, IL-4, IL-12 / IL-5 and IL-12 / IL-5 were significantly decreased after treatment in the observation group and control group (P0.05). The level of IL-17 FU IL-23 in observation group and control group was significantly lower than that before treatment (P0.05). After treatment, the above indexes in the observation group were superior to those in the control group (P0.05). Conclusion Yangyin Xiaoying recipe combined with western medicine is effective in the treatment of Graves disease and can improve the thyroid function of patients.
【作者单位】：贵阳中医学院第一附属医院内分泌科;
【基金】：贵州省科学技术基金资助项目(黔科合J字[2010]2194)
【分类号】：R581.1

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