中西医结合治疗糖尿病肾病随机对照试验的Meta分析

发布时间：2018-06-28 13:41

本文选题：中西医结合 + 糖尿病肾病　；参考：《中华中医药学刊》2017年04期

【摘要】：目的:研究分析中西医结合疗法治疗糖尿病肾病的临床效果及各相关指标的变化。方法:通过检索2005年—2015年相关期刊论文(CNKI),中国生物医学数据库(CBM),万方数据库,维普数据库(VIP)中国内公开发表的中西医结合疗法治疗糖尿病肾病的随机对照试验(RCT),运用Rev Man 5.3软件对符合纳入标准的文献进行Meta分析,比较分析中西医结合疗法与单纯西医疗法治疗糖尿病肾病的临床效果,以及治疗后空腹血糖,血肌酐,尿素氮,24 h尿蛋白量的变化。结果:经过逐步筛选,最终纳入10个随机对照试验,共960例糖尿病肾病患者,Meta分析结果显示与对照组相比,中西医结合疗法治疗糖尿病肾病的总体疗效较好,差异具有统计学意义(P0.05),患者治疗后空腹血糖,24 h尿蛋白量均降低,差异具有统计学意义(P0.05),治疗后血肌酐、尿素氮无明显降低,差异不具有统计学意义(P0.05)。结论:中西医结合治疗糖尿病肾病的疗效优于单纯西医治疗,在降低血糖、24 h尿蛋白量方面具有较好的疗效,因纳入文献样本有限以及文献质量不高,尚需大样本以及多中心随机对照双盲试验的高质量研究来加以验证。
[Abstract]:Objective: to study and analyze the clinical effect of integrated traditional Chinese and western medicine on diabetic nephropathy. Methods: Chinese Journal Full-text Database (CNKI), Chinese Biomedical Database (CBM) and Wanfang Database were searched from 2005 to 2015. A randomized controlled trial (RCT) on the treatment of diabetic nephropathy with integrated traditional Chinese and western medicine (RCT) published in China by VIP database was carried out with the software Rev Man 5.3 to conduct a meta-analysis of the literature in accordance with the inclusion criteria. To compare and analyze the clinical effect of integrated traditional Chinese and western medicine therapy and simple western medicine therapy in the treatment of diabetic nephropathy, as well as the changes of fasting blood glucose, serum creatinine and urinary protein content in 24 h after treatment. Results: a total of 960 patients with diabetic nephropathy were enrolled in 10 randomized controlled trials after gradual screening. The results of Meta-analysis showed that compared with the control group, the treatment of diabetic nephropathy by integrated traditional Chinese and western medicine was better than that of the control group. The difference was statistically significant (P0.05), fasting blood glucose and 24 h urine protein content were all decreased after treatment (P0.05), the serum creatinine and urea nitrogen were not significantly decreased after treatment (P0.05). Conclusion: the therapeutic effect of integrated traditional Chinese and western medicine in the treatment of diabetic nephropathy is better than that of western medicine alone. It has a better effect on reducing the amount of urinary protein in 24 h blood glucose, because of the limited number of literature and the low quality of literature. High-quality studies of large samples and multi-center randomized-controlled double-blind trials are needed.
【作者单位】：湖南中医药大学;
【基金】：国家自然科学基金项目(81573956) 湖南省高校创新平台开放基金项目(14K069) 湖南省教育厅研究生创新项目(CX2016B364)
【分类号】：R587.2;R692.9

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