福建地区畲族的骨密度与骨生化指标以及睾酮雌二醇之间的关系

发布时间：2018-06-28 15:05

本文选题：骨密度 + 汉族　；参考：《中国骨质疏松杂志》2016年07期

【摘要】：目的探讨福建地区畲族健康人群骨密度与骨生化指标以及睾酮雌二醇之间的关系,并与汉族人群比较,为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地20岁以上健康成年人,其中畲族1371人,汉族1432人,应用美国Osdeometer Medi Tech公司生产的DTX-200骨密度吸收仪检测骨密度,以及用罗氏公司的骨生化指标仪器及试剂盒,测量骨密度以及25羟维生素D3(25(OH)D_3)、骨钙素(BGP)、雌二醇(E_2)、睾酮(T)、甲状旁腺激素(PTH)、1型前胶原氨基末端肽(P1NP)、碱性磷酸酶(ALP)。把上述检测的数据结果输入电脑,应用SPSS17.0软件包进行数据分析。结果不管畲族和汉族的骨密度均随着年龄的增大而下降,同年龄组男性均高于女性。畲族女性除在40~49岁年龄组稍高于汉族外,其他年龄组汉族女性均高于畲族。但汉族与畲族间都没有显著性差异(P0.05)。畲族男PO女性的骨密度峰值在40~49岁年龄组,汉族的男女性的峰值在30~39岁年龄组。汉族的25(OH)D_3明显高于畲族,尤其女性在40~59岁年龄组、男性在50~69岁年龄组为正相关(P0.05)。在40~69岁中畲族男性的BGP高于汉族男性(P0.05).汉族男的E2指标均高于畲族男,且40~59年龄组尤为明显(P0.05)。P1NP在汉族男女性高于畲族男女性,其中50~59岁,70岁~79岁,和80以上3组的汉族男和畲族男P1NP指标差异显著(P0.05),50岁以上4组汉族女P1NP指标均比畲族女高,差异显著(P0.05)。经皮尔森相关分析,骨密度与E2、25(OH)D_3、T成正相关,而与PTH、BGP、P1NP成负相关。结论本研究25(OH)D3、BGP、P1NP、E2测定可以作为汉族、畲族健康人群早期检测指标,畲族的25(OH)D_3水平普遍偏低,可能与他们的生活方式或者维生素D基因有关,值得进一步研究。骨密度与25(OH)D_3、E_2、T有明显正相关,而与PTH、PINP、BCG呈负相关,与ALP无明显相关。
[Abstract]:Objective to investigate the relationship between bone mineral density (BMD) and bone biochemical index and testosterone estradiol in healthy population of she nationality in Fujian and to provide evidence for prevention and treatment of osteoporosis in this area. Methods healthy adults over 20 years old were selected from the she nationality area, including 1371 she nationality and 1432 Han nationality. Bone mineral density (BMD) was measured with DTX-200 bone mineral absorptiometry produced by Osdeometer Medi Tech. Bone mineral density (BMD) and 25 hydroxyvitamin D3 (25 (OH) D3), osteocalcin (BGP), estradiol (E2), testosterone (T), parathyroid hormone (PTH) procollagen amino-terminal peptide (P1NP), alkaline phosphatase (ALP) were measured with the bone biochemical index instrument and kit of Roche Company. The results of the above test were input into the computer and analyzed by SPSS 17.0 software package. Results the bone mineral density of she nationality and Han nationality decreased with the increase of age, and that of male was higher than that of female. The she nationality women were higher than the she nationality except in the age group of 40 ~ 49 years old and the Han nationality group. However, there was no significant difference between Han nationality and she nationality (P0.05). The peak value of bone mineral density (BMD) was in the 40 ~ 49 years old group and in the 30 ~ 39 years old group in the Han nationality. 25 (OH) D _ 3 in Han nationality was significantly higher than that in she nationality, especially in 4059 years old group for female and positive correlation for male group at 50 ~ 69 years old (P0.05). The BGP of she nationality male was higher than that of Han nationality male (P 0.05). The E _ 2 index of Han nationality male was higher than that of she nationality male, and the age group of 40 ~ 59 was more obvious than she nationality (P0.05). P1NP was higher in Han nationality than in she nationality, among them, 50 ~ 59 years old or 70 years old or 79 years old. The P1NP index of Han nationality and she nationality male was significantly higher than that of she nationality female (P0.05), and the P1NP index of Han women above 50 years old was significantly higher than that of she nationality female (P0.05). By Pearson correlation analysis, BMD was positively correlated with E _ 2O _ 25 (OH) D _ 3T, but negatively correlated with P1NP. Conclusion in this study, the determination of 25 (OH) D3 BGPP1NPE _ 2 can be used as an early detection index for the healthy population of Han and she nationality. The level of 25 (OH) D3 in she nationality is generally low, which may be related to their lifestyle or vitamin D gene, which is worthy of further study. BMD was positively correlated with 25 (OH) D _ 3C _ 2T, but negatively correlated with PINP BCG, but not with ALP.
【作者单位】：福建医科大学附属莆田市第一医院;
【基金】：民政部十一五期间老年学研究骨质疏松项目(民人科教字[2008]47-1-44) 2012年福建省医学创新课题资助项目(2012-CXB-46) 2014年福建省自然科学基金资助项目(2014J01391)
【分类号】：R580

【相似文献】