多发性骨髓瘤与系统性红斑狼疮患者血浆IL-2、TNF-α检测

发布时间：2018-07-03 02:08

  本文选题：多发性骨髓瘤 + 系统性红斑狼疮　； 参考：《安徽医科大学学报》2016年02期

【摘要】：目的检测多发性骨髓瘤(MM)("免疫过度受抑"疾病)与系统性红斑狼疮(SLE)("免疫过度激活"疾病)患者血浆白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)水平,并对结果进行分析。方法 SLE、MM患者和健康对照均于清晨空腹抽取静脉血3 ml,酶联免疫法测定血浆IL-2、TNF-α水平。结果与对照者比较,MM患者、SLE患者血浆IL-2水平差异无统计学意义;MM患者TNF-α水平显著低于对照者(P0.05),SLE患者TNF-α水平显著高于对照者(P0.05)。MM患者血浆IL-2、TNF-α水平显著低于SLE患者(P=0.01,P0.01)。年龄55岁组MM患者血浆IL-2、TNF-α均显著高于≥55岁组(P0.01,P=0.03);肾功能不全MM患者血浆IL-2水平显著高于肾功能正常MM患者(P=0.01)。有与无首诊盘形红斑的SLE患者之间,其血浆IL-2、TNF-α水平差异有统计学意义(P=0.02,P=0.02)。结论TNF-α在体内微环境的生理失衡是MM患者的"免疫过度受抑"与SLE患者"免疫异常激活"的原因之一,IL-2的影响作用则有待进一步深入。
[Abstract]:Objective to detect the levels of interleukin-2 (IL-2) and tumor necrosis factor- 伪 (TNF- 伪) in patients with multiple myeloma (MM) and systemic lupus erythematosus (SLE). Methods Plasma IL-2TNF- 伪 levels were measured by enzyme-linked immunosorbent assay (Elisa). Results there was no significant difference in plasma IL-2 levels between patients with SLE and controls. The level of TNF- 伪 in patients with MM was significantly lower than that in controls (P0.05). The level of TNF- 伪 in patients with MM was significantly lower than that in patients with SLE (P0.05). The level of TNF- 伪 in patients with MM was significantly lower than that in patients with SLE (P0.01). The plasma levels of IL-2 TNF- 伪 in MM patients aged 55 years were significantly higher than those in patients 鈮，

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