原发性甲状腺功能减退症患者血脂谱变化的特点

发布时间：2018-07-03 15:47

本文选题：原发性甲状腺功能减退症 + 小而密低密度脂蛋白胆固醇　；参考：《安徽医科大学学报》2017年09期

【摘要】：目的探讨原发性甲状腺功能减退症患者的血清脂蛋白胆固醇亚组分的变化。方法原发性甲状腺功能减退症患者38例分为临床甲状腺功能减退组(甲减组,20例)、亚临床甲状腺功能减退组(亚甲减组,18例),另选择20例健康体检者作对照(对照组)。留取患者空腹静脉血5 ml,分离血清取上清液-80℃冰箱保存,配置密度液,在不同背景密度下超速离心,采用胆固醇氧化酶法测定血清小而密低密度脂蛋白胆固醇(sd LDL-C)、高密度脂蛋白2胆固醇(HDL2-C)、高密度脂蛋白3胆固醇(HDL3-C)的水平。同时检测三碘甲状原氨酸(T3)、甲状腺素(T4)和促甲状腺素(TSH),统计分析其与血清脂蛋白胆固醇亚组分的相关性。结果 (1)甲减组和亚甲减组患者总胆固醇、三酰甘油、LDL胆固醇水平高于对照组,HDL水平低于对照组,差异有统计学意义(P0.05);(2)甲减组和亚甲减组患者sd LDL-C水平高于对照组,差异有统计学意义(P0.05);甲减组和亚甲减组血清HDL2-C低于对照组,差异有统计学意义(P0.05);HDL3-C组间比较差异无统计学意义;甲减组与亚甲减组sd LDL-C、HDL2-C、HDL3-C比较差异无统计学意义;(3)原发性甲状腺功能异常发生时,sd LDL-C水平与TSH呈正相关性(r=0.287,P=0.026),与T4呈负相关性(r=-0.267,P=0.039);与T3无相关性;HDL2-C与T3、T4呈正相关性(r=0.271、0.270,P=0.036、0.037);HDL3-C与TSH、T3、T4无明显相关性。结论甲状腺功能减退症患者的临床血脂谱及脂蛋白胆固醇亚组分产生变化,并与甲状腺功能相关。
[Abstract]:Objective to investigate the changes of serum lipoprotein cholesterol subcomponents in patients with primary hypothyroidism. Methods 38 patients with primary hypothyroidism were divided into clinical hypothyroidism group (hypothyroidism group, 20 cases), subclinical hypothyroidism group (Ya Jiajian group, 18 cases), and 20 healthy subjects as control. 5 ml of venous blood was left in the patients. The isolated sera was stored in the supernatant at -80 centigrade and stored in the refrigerator. The density liquid was configured to be centrifuged at different background density. The serum low density lipoprotein cholesterol (SD LDL-C), high density lipoprotein 2 cholesterol (HDL2-C), and high density lipoprotein 3 cholesterol (HDL3-C) were measured by the cholesterol oxidase method. At the same time, three iodonate protryptine (T3), thyroxine (T4) and thyrotropin (TSH) were measured, and the correlation between the serum lipoprotein cholesterol subcomponents was statistically analyzed. Results (1) the total cholesterol, three acylglycerol and LDL cholesterol level in the hypothyroidism and subsubtract groups were higher than those in the control group, and the HDL level was lower than the control group, the difference was statistically significant ( (2) (2) the level of SD LDL-C in the hypothyroidism and hypothyroidism group was higher than that in the control group, the difference was statistically significant (P0.05), and the serum HDL2-C in the hypothyroidism and subsubtract group was lower than the control group (P0.05), and there was no statistical difference between the HDL3-C group and the HDL3-C group. The difference was not statistically significant between the subsubtract group and the subsubtract group SD LDL-C, HDL2-C, HDL3-C. (3) there was a positive correlation between SD LDL-C level and TSH (r=0.287, P=0.026), negative correlation with T4 (r=-0.267, P=0.039), and no correlation with T3; HDL2-C and T3, T4 presented a positive correlation, and there was no significant correlation between HDL2-C and T3. Bed lipid profiles and lipoprotein cholesterol subfractions changed and correlated with thyroid function.
【作者单位】：安徽医科大学第一附属医院内分泌科安徽省内分泌代谢病省级实验室;
【基金】：公益性行业科研专项经费(编号:201402005)
【分类号】：R581.2

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