血清胎球蛋白A水平与胰岛素抵抗及颈动脉内膜中层厚度在初诊2型糖尿病患者中的相关性分析

发布时间：2018-07-03 16:57

本文选题：初诊型糖尿病 + 胎球蛋白A　；参考：《中国现代医学杂志》2017年16期

【摘要】：目的旨在探讨初诊2型糖尿病(n T2DM)患者血清胎球蛋白A(FA)水平与胰岛素抵抗(IR)及颈动脉内膜中层厚度(CIMT)的相关性。方法选取n T2DM患者100例作为病例组(T2DM组),糖耐量正常(NGT)者100例作为对照组(NGT组),采用酶联免疫吸附实验(ELISA法)试剂盒检测血清FA浓度,计算稳态模型胰岛素抵抗指数(HOMA-IR)评估IR,运用彩色超声诊断仪测定CIMT,分析血清FA浓度与各项临床资料之间的相关性。结果 T2DM组血清FA水平(368.5±15.6)mg/ml高于NGT组血清FA水平(152.7±7.1)mg/ml,差异有统计学意义(P=0.000);FA水平与HOMA-IR(r=0.483,P=0.000)、CIMT(r=0.509,P=0.000)、糖化血红蛋白(Hb A1c)(r=0.153,P=0.042)、三酰甘油(TG)(r=0.353,P=0.000)、低密度脂蛋白(LDL-C)(r=0.113,P=0.023)、体重指数(BMI)(r=0.162,P=0.024)、收缩期血压(SBP)(r=0.182,P=0.035)、空腹血糖(FPG)(r=0.422,P=0.002)及2 h葡萄糖负荷血糖(2 h OGTT)(r=0.581,P=0.000)呈正相关,与空腹血浆胰岛素(FINS)(r=-0.153,P=0.008)、2 h葡萄糖负荷血浆胰岛素(PINS)(r=-0.423,P=0.008)、高密度脂蛋白(HDL-C)(r=-0.183,P=0.011)和HOMA-β细胞胰岛素分泌指数(HOMA-IS)(r=-0.463,P=0.000)呈负相关。结论 n T2DM患者血清FA水平与IR及CIMT之间存在相关性,研究结果表明,血清FA水平可作为诊断nT2DM患者大血管病变的独立生物学标志物。
[Abstract]:Objective to investigate the correlation between serum fetal globulin A (FA) level and insulin resistance (IR) and carotid intima media thickness (CIMT) in patients with newly diagnosed type 2 diabetes (n T2DM). Methods 100 cases of n T2DM patients were selected as case group (T2DM group), 100 cases of normal glucose tolerance (NGT) were used as control group (NGT group), and enzyme linked immunosorbent assay (ELISA method) was used. The serum FA concentration was detected by the kit and the IR was evaluated by the steady-state model insulin resistance index (HOMA-IR). The correlation between the serum FA concentration and the clinical data was analyzed by the color ultrasound diagnostic instrument. The serum FA level (368.5 + 15.6) mg/ml in the T2DM group was higher than that in the NGT group (152.7 + 7.1) mg/ml, and the difference was statistically significant. (P=0.000); FA level and HOMA-IR (r=0.483, P=0.000), CIMT (r=0.509, P=0.000), glycosylated hemoglobin (Hb A1c) (r=0.153, P=0.042), three acylglycerol, low density lipoprotein, body mass index, systolic blood pressure, abdominal blood glucose, and fasting blood glucose, and 2 h glucose load blood glucose (2 h OGTT) (r=0.581, P=0.000) was positively correlated with fasting plasma insulin (FINS) (r=-0.153, P=0.008), 2 h glucose load plasma insulin (PINS) (r=-0.423, P=0.008), high density lipoprotein (0.011) and insulin secretion index of beta cells. The correlation between serum FA level and IR and CIMT in patients with T2DM shows that serum FA level can be used as an independent biomarker for the diagnosis of large vascular lesions in nT2DM patients.
【作者单位】：石河子大学医学院第一附属医院内分泌代谢科;
【基金】：国家自然科学基金地区基金项目(No:81560137;No:81560139)
【分类号】：R587.1

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