糖代谢异常与甲状腺容积变化的相关性研究

发布时间：2018-07-04 15:03

本文选题：胰岛素 + 胰岛素抵抗　；参考：《中国全科医学》2017年S2期

【摘要】：目的探讨碘超足量地区居民糖代谢紊乱与甲状腺容积变化的关系。方法 2009年10月—2010年2月,采用分层整群抽样方法,选取贵阳市社区居住10年及以上居民1 224例。研究对象均进行问卷调查、体格检查、口服葡萄糖耐量试验,采集静脉血样测定25(OH)D、甲状旁腺激素(PTH)、促甲状腺素(TSH)、尿酸、空腹血糖、餐后2 h血糖和空腹胰岛素,采集尿样测定尿碘,采用甲状腺超声测量甲状腺各叶长度。按血糖水平分为正常人群、糖尿病前期人群及糖尿病人群。结果糖尿病人群甲状腺容积(6.93±3.19)ml大于正常人群(6.29±2.15)ml(P=0.007)。甲状腺容积与TSH(r=0.115,P0.01)、HOMA-IR(r=0.148,P0.01)、胰岛素(r=0.138,P0.01)呈正相关。糖尿病前期及糖尿病是甲状腺容积增大的独立危险因素(P0.05)。结论糖代谢异常可能是影响甲状腺容积的独立危险因素。
[Abstract]:Objective to study the relationship between the disorder of glucose metabolism and thyroid volume in the area of iodine excess. Methods from October 2009 to February 2010, 1 224 residents living in Guiyang for 10 years or more were selected by stratified cluster sampling. The subjects were investigated by questionnaire, physical examination, oral glucose tolerance test, venous blood samples were collected to determine 25 (OH) D, parathyroid hormone (PTH), thyrotropin (TSH), uric acid, fasting blood glucose, 2 h postprandial blood glucose and fasting insulin. Urine samples were collected to determine urinary iodine and thyroid ultrasound was used to measure the length of each lobe of thyroid gland. According to the level of blood sugar is divided into normal people, pre-diabetes and diabetes. Results the thyroid volume in diabetic patients (6.93 卤3.19) ml was higher than that in normal subjects (6.29 卤2.15) ml (P0. 007). The thyroid volume was positively correlated with TSH (r = 0.115, P 0.01), HOMA-IR (r = 0.148, P 0.01) and insulin (n = 0.138, P 0.01). Prediabetes and diabetes were independent risk factors for thyroid volume enlargement (P0.05). Conclusion abnormal glucose metabolism may be an independent risk factor affecting thyroid volume.
【作者单位】：贵州医科大学附属医院内分泌代谢病科;
【基金】：贵州省科学技术厅资助项目[黔科合LG字(2011)016号]
【分类号】：R581

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