阻塞性睡眠呼吸暂停低通气综合征血脂异常的相关因素

发布时间：2018-07-05 12:10

本文选题：阻塞性睡眠呼吸暂停低通气综合征 + 血脂异常　；参考：《中国老年学杂志》2017年07期

【摘要】：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与血脂异常的关系及OSAHS血脂异常的危险因素。方法选择行多导睡眠监测(PSG)的患者270例,其中OSAHS组235例,对照组35例。经过问卷调查、体格检查、血脂检查及PSG监测。结果 OSAHS组的血脂异常发生率为78.297%,对照组为51.428%,差异有统计学意义(P=0.001);重度OSAHS组的发生率为83.333%,轻中度OSAHS组为70.329%,差异有统计学意义(P=0.000)。OSAHS组与对照组甘油三酯(TG)、高密度脂蛋白(HDL)水平差异有统计学意义(P0.05);重度OSAHS组与对照组总胆固醇(TC)、低密度脂蛋白(LDL)比较差异有统计学意义(P0.05)。多因素Logistic回归分析,颈围、血氧饱和度(SaO_2)低于90%时间占总睡眠时间百分比进入模型(OR=0.030、1.026,P=0.046、0.020)。结论 OSAHS与血脂异常密切相关,随着OSAHS程度的加重,血脂异常的发生率增加,慢性间歇缺氧是OSAHS血脂异常的独立危险因素。
[Abstract]:Objective to investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) and dyslipidemia and the risk factors of OSAHS dyslipidemia. Methods 270 patients with polysomnography (PSG) were selected, including 235 patients in OSAHS group and 35 patients in control group. After questionnaire, physical examination, blood lipid test and PSG monitoring. Results the incidence of dyslipidemia in the OSAHS group was 78.2977.The difference was statistically significant (P0.001) between the OSAHS group and the control group (P < 0.001), while the incidence rate in the severe OSAHS group was 83.333 and that in the mild to moderate OSAHS group was 70.329B. the difference was statistically significant (P < 0.01). The difference between the OSAHS group and the control group was significant (TG) and high-density fat egg (TG). White (HDL) level was significantly different (P0.05), severe OSAHS group and control group total cholesterol (TC), low density lipoprotein (LDL) difference was statistically significant (P0.05). Multivariate logistic regression analysis, neck circumference, blood oxygen saturation (SaOs2) less than 90% of the total sleep time percentage into the model (ORO 0.030 ~ 1.026, P = 0.046 ~ 0.020). Conclusion OSAHS is closely related to dyslipidemia. With the severity of OSAHS, the incidence of dyslipidemia increases. Chronic intermittent hypoxia is an independent risk factor for OSAHS dyslipidemia.
【作者单位】：郑州大学第一附属医院河南省呼吸疾病研究所河南省高等学校临床医学重点学科开放实验室;
【基金】：卫生部国家临床重点专科建设项目(卫办医政函〔2012〕649号)
【分类号】：R766;R589.2

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