口服补充n-3多不饱和脂肪酸对糖尿病病人血糖和血脂影响的Meta分析

发布时间：2018-07-06 16:51

本文选题：n-多不饱和脂肪酸 + 糖尿病　；参考：《肠外与肠内营养》2016年04期

【摘要】：目的:系统评价糖尿病病人添加富含n-3多不饱和脂肪酸(PUFA)的营养补充剂是否可以改善病人血糖和血脂的状况。方法:检索MEDLINE、EMBASE、Cochrane对照试验中心注册数据库(CENTRAL),检索语言为英语,检索起止时间为2000年至2014年。检索词为Diabetes,n-3 polyunsaturated fatty acid,fish oil,clinical trial。纳入对糖尿病病人添加n-3 PUFA的随机对照试验,采用Jadad量表进行研究质量评价,使用Rev Man 5.2软件进行Meta分析。结果:最终纳入6项来自5个国家的高质量研究数据资料。n-3 PUFA组病人血清瘦素水平低于对照组,且差异有统计学意义。随机血糖、糖化血红蛋白、胰岛素、三酰甘油、胆固醇、高密度脂蛋白、低密度脂蛋白和脂联素等,两组之间差异均无统计学意义。结论:现有临床证据不能证明膳食补充n-3 PUFA对改善糖尿病病人的血糖和血脂状况有益。
[Abstract]:Aim: to evaluate whether dietary supplements rich in n-3 polyunsaturated fatty acids (PUFA) can improve blood glucose and blood lipids in diabetic patients. Methods: the registration database of MEDLINE EMBASEN Cochrane controlled trial Center (CENTral) was searched in English from 2000 to 2014. The key word is Diabetesin n-3 polyunsaturated fatty acidfish. A randomized controlled trial of adding n-3 PUFA to diabetic patients was carried out. Jadad scale was used to evaluate the quality of the study, and Rev Man 5.2 software was used for meta-analysis. Results: the serum leptin levels of patients in the n-3 PUFA group were significantly lower than those in the control group. Random blood glucose, glycosylated hemoglobin, insulin, triglyceride, cholesterol, high density lipoprotein, low density lipoprotein and adiponectin had no significant difference between the two groups. Conclusion: the available clinical evidence does not prove that dietary supplement of n-3 PUFA is beneficial to improve blood glucose and blood lipid in diabetic patients.
【作者单位】：天津医科大学第二医院营养科;天津市第三中心医院营养科;解放军白求恩国际和平医院营养科;天津医科大学第二医院胃肠外科;
【基金】：天津市卫计委科技基金项目(2015KZ107) 河北省卫计委科研基金(20150387)
【分类号】：R587.1;R459.3

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