红细胞分布宽度对系统性红斑狼疮疾病活动度评估的临床价值

发布时间：2018-07-06 19:14

本文选题：系统性红斑狼疮 + 红细胞分布宽度　；参考：《安徽医科大学学报》2017年12期

【摘要】：目的探讨系统性红斑狼疮(SLE)初诊患者红细胞分布宽度(RDW)与疾病严重程度间可能存在的关系。方法以190例健康人群作为对照组,回顾性分析初诊的181例SLE患者相关临床数据,如C-反应蛋白(CRP)、红细胞沉降率(ESR)、补体(C)、免疫球蛋白、红细胞分布宽度(RDW)、SLE疾病活动指数(SLEDAI-2K)等。依据国际通用的SLEDAI-2K准则评判SLE患者的疾病活动情况,对患者进行分组。分析各组间RDW指标的差异及SLEDAI-2K评分与RDW之间的相关性。结果 SLE患者的RDW明显高于对照组(t=16.36,P0.001);SLE患者的RDW与ESR以及CRP呈正相关性(r=0.628、0.663,P0.001),与C3及C4呈负相关性(r=-0.348、-0.273,P0.001);RDW在SLE患者不同活动组间差异有统计学意义(F=99.66,P0.001),且与SLEDAI-2K评分呈正相关性(r=0.725,P0.001),4组间两两分别进行比较差异均有统计学意义(P0.05)。结论 RDW具有潜在评估SLE初诊患者疾病活动度的临床价值。
[Abstract]:Objective to investigate the relationship between RDW and disease severity in newly diagnosed patients with systemic lupus erythematosus (SLE). Methods the clinical data of 181 newly diagnosed SLE patients, such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), complement (C), immunoglobulin, erythrocyte distribution width (RDW) and disease activity index (SLEDAI-2K) of SLE, were analyzed retrospectively. According to the international SLEDAI-2K criteria, the disease activity of SLE patients was evaluated and the patients were divided into groups. The difference of RDW index and the correlation between SLEDAI-2K score and RDW were analyzed. Results the RDW of SLE patients was significantly higher than that of controls (tn16.36 / P0.001). There was a positive correlation between RDW and ESR and CRP in SLE patients (r = 0.628), and a negative correlation between RDW and C _ 3 and C _ 4 (r-0.348- 0.273n P0.001). There was a significant difference between RDW and SLEDAI-2K score in SLE patients (F _ (99.66) P _ (0.001), and there was a positive correlation between RDW and SLEDAI-2K score in SLE patients. There were significant differences among 4 groups (P 0.05). Conclusion RDW has potential clinical value in evaluating disease activity of newly diagnosed SLE patients.
【作者单位】：安徽医科大学第二附属医院检验科;
【基金】：国家自然科学基金(编号:81171662) 安徽医科大学校科研基金(编号:2017xkj042)
【分类号】：R446.11;R593.241

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